{"id":"W2332215509","doi":"10.1021/cb500109e","title":"Identification of a First Enzymatic Activator of a 17β-Hydroxysteroid Dehydrogenase","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Activator (genetics); Estrone; Enzyme; Dehydrogenase; Hydroxysteroid dehydrogenase; HEK 293 cells; Transfection; Chemistry; Steroid; Biochemistry; Enzyme activator; Substituent; Endogeny; Biology; Stereochemistry; Hormone; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001890755,0.0001245959,0.0002464006,0.00003718393,0.0000208462,0.00000245602,0.000208549,0.0003283698,0.000005964023],"category_scores_gemma":[0.0003372551,0.0001048364,0.0001051846,0.00008603399,0.0001909224,0.000002433969,0.00008927031,0.00008324509,0.000009416999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007166687,"about_ca_system_score_gemma":0.00001805844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006784431,"about_ca_topic_score_gemma":8.347951e-7,"domain_scores_codex":[0.9990539,0.00007518136,0.0003882972,0.000251517,0.00005787168,0.0001732203],"domain_scores_gemma":[0.9992175,0.00006165378,0.0002452544,0.000354656,0.00005954276,0.00006137515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007791429,0.00009345108,0.001227303,0.00007205315,0.00007462121,2.152464e-7,0.00002490311,0.000003262109,0.9975872,0.0002186055,0.0001283764,0.0004920968],"study_design_scores_gemma":[0.0004844477,0.0002518594,0.00005998116,0.00001736625,0.00002881788,0.00001108058,0.000007256222,0.000156106,0.9977213,0.0002314897,0.0009266821,0.000103631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986273,0.0003991113,0.0005233225,0.00006670202,0.00005927319,0.0001317843,0.00001328869,0.000008731575,0.0001704839],"genre_scores_gemma":[0.9995313,0.00005578254,0.0001276657,0.00003868235,0.00006679359,0.00001840426,0.0001205847,0.00001334587,0.00002748425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001167322,"threshold_uncertainty_score":0.4275103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004112345734169214,"score_gpt":0.2254380458173055,"score_spread":0.2213257000831363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}