{"id":"W2332215509","doi":"10.1021/cb500109e","title":"Identification of a First Enzymatic Activator of a 17β-Hydroxysteroid Dehydrogenase","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Activator (genetics); Estrone; Enzyme; Dehydrogenase; Hydroxysteroid dehydrogenase; HEK 293 cells; Transfection; Chemistry; Steroid; Biochemistry; Enzyme activator; Substituent; Endogeny; Biology; Stereochemistry; Hormone; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001661593,0.0002269228,0.0002536691,0.0001483019,0.0001139813,0.0003736946,0.000195401,0.0003076248,0.001821003],"category_scores_gemma":[0.0002112811,0.0001128362,0.000283244,0.0001270316,0.0002357253,0.0001764266,0.0002014109,0.0005971364,0.0007862374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002579973,"about_ca_system_score_gemma":0.0002826826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002535525,"about_ca_topic_score_gemma":0.0003541482,"domain_scores_codex":[0.9998811,0.00002835534,0.000008250167,0.00002517293,0.00002916979,0.00002786559],"domain_scores_gemma":[0.9998385,0.00004438681,0.00002034005,0.00001950629,0.00003393088,0.00004327502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009227195,0.0000245227,0.0002774344,0.00004847264,0.000005687727,0.0001179127,0.00002185212,0.00006283507,0.9957862,0.0003574041,0.00004994898,0.00315546],"study_design_scores_gemma":[0.000007278462,0.0002329094,0.0009134785,0.000003797294,0.000008471232,0.0002409418,0.0000174214,0.0001838969,0.9926291,0.00007363602,0.00568412,0.000004800834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9511065,0.01224741,0.02779594,0.0007295198,0.0002217587,0.000161259,0.0006223209,0.0001884791,0.006926758],"genre_scores_gemma":[0.9771414,0.003234823,0.01246902,0.0001330031,0.00005458402,0.00003055789,0.0005679425,0.00002203987,0.006346508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001821003,"threshold_uncertainty_score":0.006091893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004112345734169214,"score_gpt":0.2254380458173055,"score_spread":0.2213257000831363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}