{"id":"W2332274857","doi":"10.1097/jcp.0b013e318218d339","title":"Predicting Dopamine D2 Receptor Occupancy From Plasma Levels of Antipsychotic Drugs","year":2011,"lang":"en","type":"review","venue":"Journal of Clinical Psychopharmacology","topic":"Medical Imaging Techniques and Applications","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Janssen Pharmaceuticals; Astellas Pharma; Otsuka Pharmaceutical; Dainippon Sumitomo Pharma; Pfizer Health Research Foundation; Eli Lilly and Company","keywords":"Antipsychotic; Risperidone; Olanzapine; Confidence interval; Occupancy; Dopamine receptor D2; Internal medicine; Clozapine; Medicine; Positron emission tomography; Schizophrenia (object-oriented programming); Nuclear medicine; Psychiatry; Dopamine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002635065,0.0004870062,0.005412466,0.000381374,0.00004503939,0.000008923611,0.000841559,0.0009611689,0.003492381],"category_scores_gemma":[0.001323744,0.0003447245,0.002054124,0.0004398153,0.0005089676,0.00008196964,0.0001050716,0.003419662,0.0001061733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005642892,"about_ca_system_score_gemma":0.0008601514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007572382,"about_ca_topic_score_gemma":2.833896e-7,"domain_scores_codex":[0.9913616,0.0006533451,0.006551556,0.000544928,0.0004927782,0.0003958124],"domain_scores_gemma":[0.9888614,0.003053476,0.006168839,0.0006164412,0.0005316741,0.0007682057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009682121,0.001539887,0.0006476521,0.00301667,0.001480685,0.00006348923,0.00003479165,2.356994e-8,0.00007389519,0.00004124916,0.0745445,0.9175889],"study_design_scores_gemma":[0.004919484,0.00105819,0.0003142155,0.01258084,0.005099663,0.0002708685,0.00000926215,0.00002004219,0.00002292418,0.0002580248,0.9752032,0.0002433313],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00748535,0.9821376,0.0004360219,0.001101236,0.006026486,0.001139217,0.0002369304,0.00006777961,0.001369446],"genre_scores_gemma":[0.0009037849,0.9730566,0.02062804,0.0006629947,0.004260649,0.00003023218,0.00002925049,0.0000850895,0.0003433584],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9173456,"threshold_uncertainty_score":0.9999005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2063204772785924,"score_gpt":0.5291217474188604,"score_spread":0.322801270140268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}