{"id":"W2332301040","doi":"10.4172/2161-1459.1000143","title":"Dual-acting 5-Fluorodeoxyuridine (FUdR) Prodrugs: Cell Death Induced by 3’-O-retinoyl-5-fluoro-2’-deoxyuridine and 5’-O-[bis(2,2,2,-trichloroethyl) phosphoryl-3’-O-butanoyl]-5-fluoro-2’-deoxyuridine","year":2013,"lang":"en","type":"article","venue":"Clinical and Experimental Pharmacology","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Prodrug; Deoxyuridine; Pharmacology; Chemistry; Stereochemistry; Medicine; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007360629,0.0009263551,0.001019105,0.0001040484,0.0004813109,0.0002535911,0.0004968782,0.0008679823,0.0003378338],"category_scores_gemma":[0.0002144109,0.0008465988,0.000277952,0.0002389987,0.0008354646,0.0001030163,0.0009624613,0.0008771155,0.00005782669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006835174,"about_ca_system_score_gemma":0.0002288402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001397234,"about_ca_topic_score_gemma":0.000001936428,"domain_scores_codex":[0.9946703,0.0004158892,0.001451767,0.001927581,0.0003661985,0.001168248],"domain_scores_gemma":[0.9976028,0.0002308953,0.0005116561,0.0005576758,0.0002350894,0.0008618872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005021091,0.0008989494,0.003095213,0.0001193959,0.0001943292,0.00002728816,0.0001317625,0.000002035726,0.9751702,0.00005656796,0.01602639,0.003775769],"study_design_scores_gemma":[0.004820716,0.002114043,0.0003958862,0.00002771004,0.0001447172,0.0001046146,0.0006506185,0.0001492649,0.9522787,0.0001532635,0.03817289,0.0009875752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701322,0.02333437,0.00008832313,0.001035175,0.001187578,0.001241371,0.00004016538,0.0001201108,0.002820717],"genre_scores_gemma":[0.9873447,0.003648848,0.0009298694,0.002169017,0.001577642,0.0004603707,0.0002338422,0.0001463918,0.003489332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02289148,"threshold_uncertainty_score":0.9993985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767678753961839,"score_gpt":0.315202442996052,"score_spread":0.2975256554564337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}