{"id":"W2332306248","doi":"10.1021/np4004905","title":"Permeability and Conjugative Metabolism of Flaxseed Lignans by Caco-2 Human Intestinal Cells","year":2014,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Phytoestrogen effects and research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of Saskatchewan","funders":"","keywords":"Lignan; Enterolactone; Caco-2; Chemistry; Permeation; Metabolism; Intestinal permeability; Biochemistry; Chromatography; Biology; In vitro; Stereochemistry; Phytoestrogens; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001099574,0.000131582,0.0005112439,0.0001126074,0.00006378122,0.00001398044,0.0001139277,0.00005386791,0.0000112445],"category_scores_gemma":[0.001309867,0.00007918839,0.0000884909,0.0001750258,0.0003054303,0.0001302416,0.00004765704,0.0006519251,0.000001405205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004289345,"about_ca_system_score_gemma":0.0001360407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002543957,"about_ca_topic_score_gemma":9.901512e-7,"domain_scores_codex":[0.9986008,0.0001849603,0.0003949211,0.0001791293,0.0004349256,0.0002052791],"domain_scores_gemma":[0.9981962,0.0001486766,0.0003144517,0.0001707485,0.001015165,0.000154702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002580158,0.0001428706,0.001134756,0.0002342919,0.00008278209,0.00001449247,0.000243804,0.000001130906,0.9934104,0.00006422507,0.002610459,0.001802752],"study_design_scores_gemma":[0.001602635,0.001436527,0.04664984,0.0002113509,0.0001293544,0.0003190983,0.0000768867,0.00008152461,0.9475792,0.0002462513,0.00157553,0.00009177544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944276,0.003091424,0.000007715395,0.001814096,0.0002396176,0.0002386718,0.000004335623,0.000005285673,0.0001713163],"genre_scores_gemma":[0.9983047,0.00004281485,0.0007426571,0.00007521009,0.0005037209,7.066596e-7,0.000002491774,0.00001101208,0.0003166443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04583119,"threshold_uncertainty_score":0.3229209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069167568207808,"score_gpt":0.2886266702832621,"score_spread":0.277934994601184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}