{"id":"W2332364903","doi":"10.1021/acssensors.5b00306","title":"In Vitro Selection in Serum: RNA-Cleaving DNAzymes for Measuring Ca<sup>2+</sup> and Mg<sup>2+</sup>","year":2016,"lang":"en","type":"article","venue":"ACS Sensors","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"China Scholarship Council; University of Waterloo; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Deoxyribozyme; DNA; RNA; Chemistry; Bioanalysis; In vitro; Molecular biology; Computational biology; Biochemistry; Gene; Nanotechnology; Biology; Chromatography; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000365289,0.0002636219,0.0003000758,0.0001975009,0.00009821974,0.00003213436,0.0001191154,0.0002774259,0.000002005455],"category_scores_gemma":[0.0002855787,0.0002110169,0.00009558572,0.0002166082,0.00008865065,0.00002543301,0.00008358878,0.000126381,0.000002538063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007876197,"about_ca_system_score_gemma":0.00003324704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008774503,"about_ca_topic_score_gemma":0.00008936208,"domain_scores_codex":[0.998354,0.00009873105,0.0003471826,0.0006000241,0.0001395602,0.0004605483],"domain_scores_gemma":[0.9994297,0.0000585838,0.00009613107,0.000229328,0.0001076576,0.00007856997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002069273,0.00004122738,0.002307596,0.00002480768,0.00004038521,0.000007213898,0.0001370608,0.0005907576,0.9856828,0.000007824747,0.0002902057,0.0106632],"study_design_scores_gemma":[0.0008304658,0.0001327037,0.0005356801,0.0000769859,0.00002711272,0.00003288845,0.0002940505,0.003609514,0.9905567,0.0001927468,0.003366966,0.0003441603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980696,0.0001684548,0.000623627,0.0006890971,0.00001828622,0.0002600119,0.0000296725,0.00004728477,0.0000939396],"genre_scores_gemma":[0.9950696,0.0003142385,0.003380107,0.0002173097,0.0001936786,0.00002134348,0.00002031612,0.00003973181,0.0007436891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01031904,"threshold_uncertainty_score":0.8605018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138691129820786,"score_gpt":0.2516690786390698,"score_spread":0.240282167340862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}