{"id":"W2332398369","doi":"10.1001/jamapediatrics.2016.0033","title":"Assessing the Diagnostic Properties of a Graded Oral Provocation Challenge for the Diagnosis of Immediate and Nonimmediate Reactions to Amoxicillin in Children","year":2016,"lang":"en","type":"article","venue":"JAMA Pediatrics","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":305,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; McGill University; Montreal Children's Hospital; McGill University Health Centre","funders":"","keywords":"Medicine; Amoxicillin; Interquartile range; Cohort; Atopy; Pediatrics; Allergy; Univariate analysis; Provocation test; Cohort study; Retrospective cohort study; Multivariate analysis; Internal medicine; Antibiotics; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006716152,0.0001530319,0.0002861863,0.0002559107,0.0001024748,0.00002549828,0.0001302417,0.0001110142,0.000001420188],"category_scores_gemma":[0.006384592,0.00007496476,0.00007750564,0.0005619259,0.0001317707,0.0002948722,0.00006033364,0.0001859234,0.000004276897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009712699,"about_ca_system_score_gemma":0.0002155015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003401472,"about_ca_topic_score_gemma":0.00007145912,"domain_scores_codex":[0.9986647,0.00007530073,0.000486838,0.0002364033,0.0002881855,0.0002485299],"domain_scores_gemma":[0.9962758,0.002765799,0.0002819881,0.0003344479,0.0002534153,0.00008852001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001005904,0.001339644,0.7119343,0.000717554,0.000214295,0.000003076896,0.00453093,0.00008214007,0.02101608,0.0006958909,0.0003053345,0.2590602],"study_design_scores_gemma":[0.00216489,0.0001328498,0.9875896,0.0003397624,0.0004646163,0.00001481845,0.001069652,0.00009235336,0.006796366,0.0001625043,0.001022277,0.0001503119],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827864,0.001004862,0.0002530023,0.01350492,0.000188314,0.002134169,0.00004461578,0.00002325177,0.0000605178],"genre_scores_gemma":[0.9932945,0.005009839,0.000319776,0.00009203229,0.0004073056,0.0008044692,0.00000717814,0.0000286689,0.00003617427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2756553,"threshold_uncertainty_score":0.7643414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05155795338849146,"score_gpt":0.3093030865017138,"score_spread":0.2577451331132224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}