{"id":"W2332439340","doi":"10.1021/jm500941m","title":"Natural Products in Medicine: Transformational Outcome of Synthetic Chemistry","year":2014,"lang":"en","type":"review","venue":"Journal of Medicinal Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Chemistry; Combinatorial chemistry; Biochemical engineering; Metabolic stability; Drug discovery; Pharmacokinetics; Natural product; Nanotechnology; Pharmacology; Computational biology; Organic chemistry; Biochemistry; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003920373,0.0006067646,0.0005130654,0.0009161788,0.0003444873,0.0007665122,0.0003545741,0.0006018896,0.002635998],"category_scores_gemma":[0.0003132737,0.0002580987,0.0003649635,0.0009742002,0.0008075063,0.001245975,0.0006971356,0.001771607,0.001750874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005565412,"about_ca_system_score_gemma":0.0005421684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003418121,"about_ca_topic_score_gemma":0.0005927602,"domain_scores_codex":[0.9998369,0.00002969706,0.00001494412,0.00003104518,0.00007006816,0.00001730642],"domain_scores_gemma":[0.9998926,0.00005144325,0.0000150773,0.000009529069,0.00002102058,0.00001043532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008399723,0.0001787542,0.0002460261,0.0148468,0.00006921968,0.0008584693,0.000349417,0.001411009,0.05386117,0.06077338,0.01172116,0.8556007],"study_design_scores_gemma":[0.00001301695,0.0001900863,0.0003677623,0.001021234,0.00002727107,0.001509941,0.00008650843,0.0001890246,0.0181419,0.009184777,0.9692404,0.00002798619],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002967538,0.9746599,0.004556508,0.0007410589,0.0007462061,0.00003712443,0.00006031552,0.00003896254,0.01619237],"genre_scores_gemma":[0.02190313,0.9689543,0.004222258,0.0004199574,0.0004198273,0.00004198255,0.00006483807,0.00001209032,0.003961734],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002635998,"threshold_uncertainty_score":0.008818269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03477197346768406,"score_gpt":0.32878996934219,"score_spread":0.2940179958745059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}