{"id":"W2332453203","doi":"10.1016/j.joca.2016.01.705","title":"Connective tissue growth factor deficiency in adult articular cartilage promotes cartilage degeneration at early timepoints in mouse posttraumatic osteoarthritis","year":2016,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"CTGF; Aggrecan; Cartilage; Chondrogenesis; Matricellular protein; Osteoarthritis; Chondrocyte; Growth factor; Connective tissue; Endochondral ossification; Cartilage oligomeric matrix protein; Type II collagen; Endocrinology; Chemistry; Internal medicine; Medicine; Extracellular matrix; Pathology; Cell biology; Anatomy; Biology; Articular cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004202214,0.0006641754,0.0005193947,0.001376366,0.0004350542,0.000915561,0.0004218971,0.0007450027,0.00206626],"category_scores_gemma":[0.0002894999,0.0007411491,0.0006845441,0.0005005267,0.0009015856,0.0006400946,0.0004692705,0.001863343,0.0008080952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007648876,"about_ca_system_score_gemma":0.0005141736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002212343,"about_ca_topic_score_gemma":0.006375835,"domain_scores_codex":[0.9992631,0.0000745111,0.00009765581,0.0001173335,0.0001852479,0.0002621345],"domain_scores_gemma":[0.9989594,0.00007703503,0.0003714526,0.00007808154,0.0000805907,0.0004333816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004056208,0.00006040462,0.0002111615,0.00002865057,0.00000489872,0.00008537847,0.00002653158,0.00002338114,0.9985832,0.0001149713,0.00002821353,0.000427656],"study_design_scores_gemma":[0.00004112188,0.0005593385,0.008534179,0.00001851291,0.00003743454,0.0003019462,0.0001569714,0.0003067769,0.988891,0.00008366069,0.001057524,0.00001149046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909855,0.003870933,0.002726377,0.0001791888,0.00007542255,0.00004150953,0.0007225676,0.0001183829,0.001280229],"genre_scores_gemma":[0.9865807,0.001460522,0.001862634,0.0001096922,0.00002468153,0.00007592301,0.0005725769,0.00006426907,0.00924896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002212343,"threshold_uncertainty_score":0.006912291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01051206803053913,"score_gpt":0.2414792780560961,"score_spread":0.2309672100255569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}