{"id":"W2332604050","doi":"10.1158/1535-7163.targ-11-b23","title":"Abstract B23: Real-time dynamic assessment of RAF-signal transduction capacity as a predictive biomarker in patients with advanced neuroendocrine tumor (aNET) treated with sorafenib (S) and metronomic cyclophosphamide (mC): The SORNET study.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Basal (medicine); Pharmacodynamics; Sorafenib; Peripheral blood mononuclear cell; Cyclophosphamide; Oncology; Pharmacology; MAPK/ERK pathway; Internal medicine; Signal transduction; Pharmacokinetics; Chemotherapy; In vitro; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000757604,0.0006448575,0.0007620201,0.0002583355,0.0002483847,0.0008723132,0.0002746313,0.0005719474,0.002027041],"category_scores_gemma":[0.0005766892,0.0002457235,0.00040433,0.0002630963,0.0003301493,0.0003720841,0.0001997617,0.001105046,0.0005602166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005050816,"about_ca_system_score_gemma":0.0004342137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003571589,"about_ca_topic_score_gemma":0.0005749445,"domain_scores_codex":[0.9997824,0.00007970996,0.00001435775,0.00006918787,0.00002945991,0.00002493891],"domain_scores_gemma":[0.9995347,0.00007850915,0.00009830186,0.00003017874,0.00004049816,0.0002178243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4249545,0.01767056,0.2303507,0.0004688509,0.0009229726,0.0008372647,0.0003198513,0.003242855,0.2246685,0.0001795381,0.003755829,0.09262872],"study_design_scores_gemma":[0.04463243,0.342494,0.5327632,0.00005282225,0.001015337,0.002077542,0.0002831642,0.01144246,0.05775858,0.0003965283,0.006952074,0.0001316882],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983814,0.0004326653,0.0001612619,0.00005939265,0.00002688504,0.0001269733,0.0003990331,0.00001878088,0.0003935824],"genre_scores_gemma":[0.9977995,0.0001206763,0.0005274785,0.00008817758,0.00003045119,0.0002100377,0.0006928187,0.000006152386,0.0005247978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002027041,"threshold_uncertainty_score":0.006781101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558948879398097,"score_gpt":0.287394194833596,"score_spread":0.271804706039615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}