{"id":"W2332636707","doi":"10.1213/ane.0000000000000558","title":"Propofol (Diprivan®) and Intralipid® Exacerbate Insulin Resistance in Type-2 Diabetic Hearts by Impairing GLUT4 Trafficking","year":2014,"lang":"en","type":"article","venue":"Anesthesia & Analgesia","topic":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta","funders":"Canadian Institutes of Health Research; Universität Zürich; Heart and Stroke Foundation of Canada","keywords":"GLUT4; Internal medicine; Endocrinology; Insulin resistance; Medicine; Glycogen; AMPK; Glucose transporter; Insulin; Protein kinase B; Propofol; Protein kinase C; Protein kinase A; Pharmacology; Kinase; Phosphorylation; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724628,0.0004572782,0.0002730552,0.000166266,0.00007675397,0.000219562,0.0002525356,0.0002920695,0.001344385],"category_scores_gemma":[0.0001094081,0.0001283327,0.0003209891,0.0001024241,0.0001859305,0.0002041994,0.0001734732,0.0005233151,0.0002382342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001514862,"about_ca_system_score_gemma":0.0001798504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001983264,"about_ca_topic_score_gemma":0.0003012444,"domain_scores_codex":[0.9999189,0.0000140486,0.000008207958,0.00001589186,0.00001617894,0.00002673155],"domain_scores_gemma":[0.9999173,0.000008289165,0.00003818037,0.00000625517,0.000005053615,0.0000250365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004032858,0.0003911713,0.0008031931,0.0001278504,0.00003346052,0.000175422,0.00001954223,0.00005055892,0.9872241,0.00007378869,0.00008866651,0.006979445],"study_design_scores_gemma":[0.001063886,0.01347283,0.02202848,0.00004048469,0.0001763785,0.001237031,0.00008652636,0.0008978046,0.9586607,0.00009039753,0.002233452,0.0000121655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971643,0.001270507,0.0007818523,0.00009296391,0.00003467549,0.00002703941,0.00005781522,0.00004642554,0.0005243379],"genre_scores_gemma":[0.9938845,0.001945961,0.001847429,0.0001848379,0.00003951849,0.0001016993,0.000287347,0.00001749048,0.001691224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001344385,"threshold_uncertainty_score":0.004497409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007612292503763393,"score_gpt":0.2396481381184808,"score_spread":0.2320358456147174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}