{"id":"W2332636707","doi":"10.1213/ane.0000000000000558","title":"Propofol (Diprivan®) and Intralipid® Exacerbate Insulin Resistance in Type-2 Diabetic Hearts by Impairing GLUT4 Trafficking","year":2014,"lang":"en","type":"article","venue":"Anesthesia & Analgesia","topic":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; University of Alberta","funders":"Canadian Institutes of Health Research; Universität Zürich; Heart and Stroke Foundation of Canada","keywords":"GLUT4; Internal medicine; Endocrinology; Insulin resistance; Medicine; Glycogen; AMPK; Glucose transporter; Insulin; Protein kinase B; Propofol; Protein kinase C; Protein kinase A; Pharmacology; Kinase; Phosphorylation; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003693169,0.0002815759,0.0005754636,0.0001352268,0.0001091763,0.00005032552,0.0001144863,0.000181785,0.00004865491],"category_scores_gemma":[0.0001478155,0.0002490275,0.00008032718,0.0003072728,0.0001555485,0.0001178533,0.00002423085,0.0003090849,0.00002837189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006134396,"about_ca_system_score_gemma":0.00005543953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007078228,"about_ca_topic_score_gemma":0.00004898783,"domain_scores_codex":[0.9980497,0.0001330044,0.0004654985,0.000492316,0.0002923619,0.0005671137],"domain_scores_gemma":[0.9990937,0.0001294645,0.00007127904,0.0003343669,0.00008741295,0.0002837507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00599788,0.0020175,0.8342144,0.002074721,0.0003150123,0.001845516,0.005676723,0.00003800844,0.02223024,0.01063449,0.01213188,0.1028237],"study_design_scores_gemma":[0.02070679,0.00395895,0.7215444,0.003679232,0.0005838413,0.0007856386,0.0004747818,0.006384412,0.002899938,0.002866733,0.2339052,0.002210126],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911038,0.002763684,0.00006284154,0.004530662,0.00004030307,0.0005289717,9.530488e-7,0.00008630226,0.0008825283],"genre_scores_gemma":[0.9970767,0.0003005002,0.0005162284,0.001475176,0.0001112254,0.00003991789,0.00002158252,0.00004134215,0.0004173649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2217733,"threshold_uncertainty_score":0.9999962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007612292503763393,"score_gpt":0.2396481381184808,"score_spread":0.2320358456147174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}