{"id":"W2332803544","doi":"10.1002/dvdy.24048","title":"Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo","year":2014,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Institute of Zoology, Chinese Academy of Sciences; RIKEN; Feinberg School of Medicine; University of California, San Francisco; University of California, Santa Barbara; National Institutes of Health; Tokyo Metropolitan University; Technion-Israel Institute of Technology; University of Tokushima; Genome Institute of Singapore; Wakayama Medical University; Chinese Academy of Sciences; University of Queensland; Monash University; National Cancer Institute; University of Bristol; School of Medicine; Newcastle University; University of Dundee; University of South Florida; University of Oxford; Brigham Young University; University College London; Cancer Research UK; Wellcome Trust; National Tsing Hua University; Montana State University; University of Illinois at Urbana-Champaign; University of Dayton; Massachusetts General Hospital; University of Minnesota; Case Western Reserve University; University of Arizona; Northwestern University; University of Miami; Stowers Institute for Medical Research; University of South Carolina; Cincinnati Children's Hospital Medical Center; Brown University; Harvard University; University of Washington; University of Nebraska Medical Center; University of Toronto; Yale University","keywords":"Adherens junction; Sarcomere; Tropomyosin; Actinin; Myofibril; Cell biology; Biology; Actin; Myofilament; Morphogenesis; Myocyte; Nebulin; Embryonic stem cell; Titin; Anatomy; Cell; Cytoskeleton; Biochemistry; Gene; Cadherin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706922,0.0004511682,0.0001538589,0.000408568,0.000232341,0.0002847969,0.0003543019,0.0004826624,0.00211997],"category_scores_gemma":[0.0001518376,0.0003096106,0.0002002297,0.0000987309,0.0002051633,0.0002220828,0.0002989791,0.0005257727,0.0005971942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003293291,"about_ca_system_score_gemma":0.0002152312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007381074,"about_ca_topic_score_gemma":0.001386576,"domain_scores_codex":[0.9998471,0.00001399079,0.00002192908,0.00003930616,0.00004755184,0.00003016704],"domain_scores_gemma":[0.9997756,0.00003427713,0.00009468464,0.00001997009,0.0000194021,0.00005612897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003679153,0.000004959686,0.0003468007,0.00001836207,0.000001935725,0.0001182258,0.00001147499,0.00003028693,0.9986034,0.0001271246,0.00001771189,0.0006829774],"study_design_scores_gemma":[0.00002636608,0.0001540099,0.02462595,0.00002566513,0.00002242794,0.001014265,0.00003996489,0.0007516797,0.9677812,0.0000868843,0.005465591,0.000005963495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879292,0.002480787,0.005273318,0.00009406822,0.00002393293,0.00005726251,0.001179104,0.0001898354,0.002772604],"genre_scores_gemma":[0.9840583,0.001150424,0.006444634,0.00005753075,0.00001023662,0.00008510029,0.001151272,0.00009609764,0.006946422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00211997,"threshold_uncertainty_score":0.007091939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0208844746110674,"score_gpt":0.2598065384590805,"score_spread":0.2389220638480131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}