{"id":"W2332879878","doi":"10.1097/00007691-200206000-00009","title":"Interpatient and Intrapatient Variability in Phenytoin Protein Binding","year":2002,"lang":"en","type":"article","venue":"Therapeutic Drug Monitoring","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Phenytoin; Free fraction; Albumin; Coefficient of variation; Serum albumin; Medicine; Internal medicine; Anticonvulsant; Endocrinology; Serum concentration; Pharmacokinetics; Chemistry; Chromatography; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001757895,0.0003849443,0.0008387575,0.0007742465,0.0003175049,0.0005953801,0.0003488596,0.0003187155,0.0004885689],"category_scores_gemma":[0.00844179,0.0002217608,0.0003284301,0.0008570534,0.0004024774,0.0004220775,0.0005219484,0.0004193614,0.0001998836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003433475,"about_ca_system_score_gemma":0.0001521744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008859095,"about_ca_topic_score_gemma":0.0009665185,"domain_scores_codex":[0.9971227,0.0006432481,0.0005053843,0.0007994492,0.0007404663,0.0001887556],"domain_scores_gemma":[0.9919715,0.004057341,0.001715176,0.00105865,0.0008881816,0.000309184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004614135,0.00003637552,0.987309,0.00002411904,0.0001769338,0.0002703505,0.0003200852,0.0002091864,0.002605986,0.00002879693,0.0000831759,0.008474517],"study_design_scores_gemma":[0.000009644537,0.0003733057,0.9952955,0.000004510339,0.00006581424,0.001218938,0.0001142523,0.0009477689,0.001614396,0.00004363376,0.0002990236,0.00001324889],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983556,0.0002961823,0.0009800091,0.000009492379,0.00000680009,0.00001229901,0.0001392319,0.00001217282,0.0001883342],"genre_scores_gemma":[0.9992836,0.00004529192,0.0002923889,0.00001331246,0.000008121378,0.00001414033,0.000286236,0.000007186138,0.00004976546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001757895,"threshold_uncertainty_score":0.009296715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04011627496105127,"score_gpt":0.2949079074799841,"score_spread":0.2547916325189328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}