{"id":"W2332917663","doi":"10.1097/qai.0b013e31820eefbe","title":"A Randomized Crossover Study to Determine Relative Bioequivalence of Tenofovir, Emtricitabine, and Efavirenz (Atripla) Fixed-Dose Combination Tablet Compared With a Compounded Oral Liquid Formulation Derived From the Tablet","year":2011,"lang":"en","type":"letter","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia; Chulalongkorn University; University of Alabama at Birmingham","keywords":"Bioequivalence; Efavirenz; Emtricitabine; Tenofovir; Fixed-dose combination; Crossover study; Medicine; Pharmacology; Pharmacokinetics; Randomized controlled trial; Human immunodeficiency virus (HIV); Internal medicine; Viral load; Virology; Antiretroviral therapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007564448,0.001478263,0.004962523,0.0004663984,0.0007166297,0.001290222,0.001821428,0.003053244,0.01079328],"category_scores_gemma":[0.00827603,0.0009883902,0.002164824,0.0005710448,0.001905925,0.001631417,0.0004737782,0.004603048,0.001311122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008620655,"about_ca_system_score_gemma":0.001903394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006107556,"about_ca_topic_score_gemma":0.001038587,"domain_scores_codex":[0.9957047,0.002682637,0.0003307611,0.0005774471,0.0004098448,0.0002944865],"domain_scores_gemma":[0.9916175,0.003915071,0.001662271,0.0007447422,0.0006294234,0.001431017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9839857,0.01102278,0.0002607488,0.0001970334,0.0004815636,0.00001906201,0.00003406993,0.00003235594,0.0009545777,0.00004560048,0.0001886281,0.002777916],"study_design_scores_gemma":[0.7555037,0.2412339,0.00166125,0.00002671252,0.0004706863,0.00001762158,0.00002351184,0.0002590836,0.000291636,0.00008478168,0.000409817,0.00001733062],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800876,0.003254871,0.001080449,0.0006725136,0.002728054,0.009561346,0.0009289388,0.00009790523,0.001588298],"genre_scores_gemma":[0.9783368,0.001673309,0.003088984,0.001939459,0.001960413,0.008529563,0.0008390588,0.00003214701,0.003600438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01079328,"threshold_uncertainty_score":0.04000509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03289672565851643,"score_gpt":0.2726282544102697,"score_spread":0.2397315287517533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}