{"id":"W2333080617","doi":"10.1095/biolreprod.115.133702","title":"Role of Specificity Protein-1 and Activating Protein-2 Transcription Factors in the Regulation of the Gap Junction Protein Beta-2 Gene in the Epididymis of the Rat1","year":2016,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"University of Pennsylvania","keywords":"Chromatin immunoprecipitation; Biology; Molecular biology; Gene knockdown; Promoter; Chromatin; Transfection; Transcription factor; Transcriptional regulation; Reporter gene; Sp1 transcription factor; Transcription (linguistics); Regulation of gene expression; Messenger RNA; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001209326,0.00012031,0.0001952334,0.00005071897,0.00006114193,0.000002099323,0.0002225168,0.000192998,0.000005015244],"category_scores_gemma":[0.0003418535,0.00005044857,0.00009698385,0.0002024486,0.000448623,0.0000100209,0.00004393973,0.0001121738,6.92926e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001378389,"about_ca_system_score_gemma":0.00004056984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003855361,"about_ca_topic_score_gemma":0.0001784731,"domain_scores_codex":[0.9982101,0.0007813415,0.0004375255,0.0003461099,0.00009991452,0.0001249856],"domain_scores_gemma":[0.9987265,0.0000275015,0.0005123299,0.0006198142,0.0001069561,0.000006845005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000202422,0.00007914125,0.01902857,0.00003090131,0.00001618769,1.110272e-8,0.0004110608,0.000005472283,0.968597,0.0005306139,0.000003671162,0.01109493],"study_design_scores_gemma":[0.0002464579,0.0002376426,0.2316304,0.00004177663,0.000007130282,0.00000347675,0.0005158139,0.000002417749,0.765755,0.0007485154,0.0007653261,0.00004606214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961448,0.0005107129,0.0001172003,0.00166155,0.00007753166,0.001428457,0.00001183728,0.00000224335,0.00004566233],"genre_scores_gemma":[0.9996353,0.00003992392,0.00007324838,0.00000709712,0.0001051747,0.00007038123,0.0000108733,0.000006102583,0.00005189274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2126018,"threshold_uncertainty_score":0.2057233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02110440160342624,"score_gpt":0.2272295478527842,"score_spread":0.206125146249358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}