{"id":"W2333212218","doi":"10.1155/2000/959161","title":"Opioid Tolerance and Physical Dependence: Role of Spinal Neuropeptides, Excitatory Amino Acids and Their Messengers","year":2000,"lang":"en","type":"article","venue":"Pain Research and Management","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Calcitonin gene-related peptide; Neuropeptide; Opioid; Agonist; Chemistry; Nociception; Morphine; Opioid receptor; Pharmacology; Neuropeptide Y receptor; Physical dependence; Receptor; Endocrinology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001548926,0.0003039,0.0002958423,0.0002994927,0.0001971621,0.0004913313,0.0002022949,0.0004899554,0.002202712],"category_scores_gemma":[0.0001565108,0.00008654098,0.0001114605,0.0002546745,0.0005996135,0.0005183835,0.0003749781,0.0005137395,0.0002114383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002694982,"about_ca_system_score_gemma":0.0003471401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007591654,"about_ca_topic_score_gemma":0.001018038,"domain_scores_codex":[0.9999261,0.00001456715,0.000005851651,0.0000118792,0.0000220585,0.00001961946],"domain_scores_gemma":[0.9998622,0.00002025624,0.0000408329,0.000003583851,0.00001808169,0.00005491901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003587933,0.001741273,0.03110319,0.005690563,0.0002552867,0.004513435,0.0007567701,0.0005935549,0.3157651,0.01500527,0.003578781,0.6174088],"study_design_scores_gemma":[0.0001691718,0.0054771,0.8596764,0.001203567,0.0003125481,0.0112188,0.001416923,0.001262063,0.03190308,0.01835342,0.06889036,0.0001164998],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3660156,0.6186614,0.001335809,0.002713545,0.0002305965,0.00003536963,0.0001500699,0.00003989957,0.01081772],"genre_scores_gemma":[0.7422784,0.2484127,0.0006350147,0.0006974156,0.0004622682,0.00005030914,0.0001343398,0.000006110355,0.007323442],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002202712,"threshold_uncertainty_score":0.007368803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0247541760841758,"score_gpt":0.3140511837839762,"score_spread":0.2892970076998004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}