{"id":"W2333268966","doi":"10.17952/24aps.2015.249","title":"Structure-Based Optimization of a Potent PACE4 Inhibitor Containing a Decarboxylated P1 Arginine Mimetic","year":2015,"lang":"en","type":"article","venue":"","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada; Heart and Stroke Foundation of Canada","keywords":"Leucine; Biochemistry; Chemistry; Arginine; Peptide; Amino acid; Isoleucine; Cyclic peptide; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005746557,0.0001305312,0.000145749,0.00003655863,0.00001913752,0.00001263134,0.00008170797,0.0001631675,0.00002568782],"category_scores_gemma":[0.00009818198,0.0001047247,0.00004864396,0.0001204124,0.00004858476,0.000003814169,0.00003845239,0.00005310556,6.024497e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000134354,"about_ca_system_score_gemma":0.00007472058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001189626,"about_ca_topic_score_gemma":0.000003233207,"domain_scores_codex":[0.9992471,0.00003415425,0.0002302644,0.0002160215,0.0001326281,0.0001398016],"domain_scores_gemma":[0.9994137,0.000005078465,0.0001124564,0.0001618243,0.0001984638,0.0001085252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003036083,0.00002149487,0.001040106,0.00001300482,0.00002263783,7.316197e-7,0.00002339407,0.00759615,0.9902871,0.00002610496,0.00008474006,0.0005808793],"study_design_scores_gemma":[0.00114507,0.0004486154,0.0005036184,0.00001337003,0.00001852162,0.000005259014,0.00003464757,0.01609583,0.9813873,0.0000459752,0.0001478851,0.0001539369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784475,0.0001102949,0.02071848,0.0001598265,0.0001119011,0.0001492129,0.00002475226,0.00001873932,0.0002592893],"genre_scores_gemma":[0.9912691,0.000004194173,0.007485188,0.0002097922,0.0001060055,0.000003802938,0.0008256536,0.0000138866,0.00008234088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01323329,"threshold_uncertainty_score":0.427055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01095578515351248,"score_gpt":0.2221025049266145,"score_spread":0.211146719773102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}