{"id":"W2333488825","doi":"10.1515/dmdi.2008.23.1-2.151","title":"FREE RADICAL GENERATION BY METHYLGLYOXAL IN TISSUES","year":2008,"lang":"en","type":"review","venue":"Drug metabolism and drug interactions","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; University of Arizona; Heart and Stroke Foundation of Canada","keywords":"Methylglyoxal; Reactive oxygen species; Peroxynitrite; Oxidative stress; Chemistry; Superoxide; Glycation; Hydrogen peroxide; Biochemistry; Nitric oxide; Antioxidant; Enzyme; Diabetes mellitus; Superoxide dismutase; Catalase; Hydroxyl radical; Oxidative phosphorylation; Reactive intermediate; Biology; Endocrinology; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002067665,0.0003444945,0.0006951087,0.0002475163,0.0001536046,0.0000477153,0.000325594,0.0001371714,0.00007235863],"category_scores_gemma":[0.0004116988,0.0003087724,0.0001774246,0.0002650653,0.0001427477,0.00002629108,0.0002225975,0.0005217427,0.00002955612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003066024,"about_ca_system_score_gemma":0.0001715632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001289796,"about_ca_topic_score_gemma":0.0001560041,"domain_scores_codex":[0.9978533,0.0004362051,0.0005129498,0.0007001612,0.0002061824,0.0002912313],"domain_scores_gemma":[0.9988943,0.00007448337,0.0001704996,0.0006349634,0.00008810531,0.0001376389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001095937,0.000120955,0.000001832377,0.0003654342,0.0001022438,0.000006131377,0.0001636016,0.000007637696,0.000947474,0.0001847208,0.1987745,0.7993145],"study_design_scores_gemma":[0.0002327151,0.000005798785,0.00000222707,0.0001465455,0.00006550906,0.00008979717,0.00003220083,0.00001035927,0.001380475,0.00003335427,0.9977113,0.0002897453],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002129888,0.9971637,0.0003453949,0.0002627404,0.0006049485,0.0004340163,0.0003528161,0.00001656224,0.0006068278],"genre_scores_gemma":[0.00008076178,0.9836425,0.00106109,0.00006543373,0.001124184,0.0002029134,0.002204455,0.00005367235,0.01156495],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7990248,"threshold_uncertainty_score":0.9999365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03102396875695239,"score_gpt":0.3645150956596125,"score_spread":0.3334911269026601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}