{"id":"W2333488825","doi":"10.1515/dmdi.2008.23.1-2.151","title":"FREE RADICAL GENERATION BY METHYLGLYOXAL IN TISSUES","year":2008,"lang":"en","type":"review","venue":"Drug metabolism and drug interactions","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; University of Arizona; Heart and Stroke Foundation of Canada","keywords":"Methylglyoxal; Reactive oxygen species; Peroxynitrite; Oxidative stress; Chemistry; Superoxide; Glycation; Hydrogen peroxide; Biochemistry; Nitric oxide; Antioxidant; Enzyme; Diabetes mellitus; Superoxide dismutase; Catalase; Hydroxyl radical; Oxidative phosphorylation; Reactive intermediate; Biology; Endocrinology; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003084013,0.000649898,0.000986926,0.001263371,0.0002546444,0.0006416643,0.000655083,0.0008708594,0.002281911],"category_scores_gemma":[0.0002697437,0.0002134609,0.0003107082,0.001133361,0.0003182686,0.0009910719,0.0004636719,0.0009216487,0.002946919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004841934,"about_ca_system_score_gemma":0.0005467372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007597343,"about_ca_topic_score_gemma":0.0008881921,"domain_scores_codex":[0.9998659,0.00002064637,0.00001658364,0.00002596056,0.00005961925,0.0000113136],"domain_scores_gemma":[0.9998995,0.00002784392,0.00001961776,0.000005096561,0.00003691631,0.00001092603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009512316,0.00006738151,0.0003236358,0.01193719,0.00008544319,0.0006050757,0.00008040719,0.000285362,0.01306813,0.003969734,0.02428507,0.9451975],"study_design_scores_gemma":[0.00001796567,0.0001284036,0.001403738,0.001282951,0.00007279962,0.003906174,0.00006504155,0.00009266432,0.005472036,0.002560441,0.9849752,0.00002262901],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003696714,0.9968492,0.0003207323,0.0002639482,0.000302852,0.000005293798,0.00001493758,0.00001530675,0.001857984],"genre_scores_gemma":[0.002078671,0.9955369,0.0003892673,0.0001670944,0.000202965,0.000008587749,0.00002976681,0.000001940688,0.00158489],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002281911,"threshold_uncertainty_score":0.007633746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03102396875695239,"score_gpt":0.3645150956596125,"score_spread":0.3334911269026601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}