{"id":"W2333494261","doi":"10.1200/jco.2015.33.15_suppl.tps8599","title":"A randomized, double-blind, placebo-controlled, phase 3 study of rituximab with or without ibrutinib for Waldenstrom’s macroglobulinemia (PCYC-1127-CA).","year":2015,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Dalhousie University","funders":"","keywords":"Ibrutinib; Medicine; Bruton's tyrosine kinase; Waldenstrom macroglobulinemia; Tolerability; Rituximab; Macroglobulinemia; Internal medicine; Placebo; Oncology; Phases of clinical research; Gastroenterology; Pharmacology; Clinical trial; Tyrosine kinase; Adverse effect; Lymphoma; Chronic lymphocytic leukemia; Pathology; Leukemia; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002489756,0.002624336,0.004176118,0.000711333,0.0008435285,0.001495774,0.001585968,0.002943861,0.01459557],"category_scores_gemma":[0.002189734,0.001284563,0.001628041,0.0005519334,0.001714144,0.001731,0.0005934058,0.004887559,0.003349256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009242068,"about_ca_system_score_gemma":0.001836407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001086864,"about_ca_topic_score_gemma":0.002707295,"domain_scores_codex":[0.9990925,0.0004092092,0.00004474417,0.0001983051,0.00009038932,0.0001648733],"domain_scores_gemma":[0.9988945,0.0002414135,0.0002004633,0.00009835279,0.0000917557,0.000473502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.978694,0.01024887,0.0001709493,0.0004164209,0.000412547,0.00002633172,0.00002984119,0.0001117184,0.002108982,0.00007976127,0.0009261956,0.00677438],"study_design_scores_gemma":[0.9686379,0.03020937,0.0003751891,0.00001220647,0.0001057288,0.000009874066,0.000006709157,0.0001019019,0.0001013191,0.00006257205,0.0003707604,0.000006447053],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9235959,0.008547239,0.002487344,0.002106819,0.00309912,0.04699523,0.00490518,0.0008263397,0.007436753],"genre_scores_gemma":[0.9366213,0.004245358,0.004145104,0.003984141,0.0009567047,0.03851008,0.002561248,0.00009354571,0.008882478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01459557,"threshold_uncertainty_score":0.04882705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2601830848050988,"score_gpt":0.5382811004902589,"score_spread":0.2780980156851601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}