{"id":"W2333611280","doi":"10.2174/187221512801327406","title":"Recent Patents in siRNA Delivery Employing Nanoparticles as Delivery Vectors","year":2012,"lang":"en","type":"review","venue":"Recent Patents on DNA & Gene Sequences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Biocompatibility; Polyethylenimine; Liposome; Nanotechnology; Small interfering RNA; Chitosan; Cationic liposome; Nanoparticle; Gene delivery; Drug delivery; Chemistry; Materials science; Transfection; Biophysics; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005207398,0.001018635,0.001343981,0.0003614669,0.0001740124,0.0001198123,0.0009874111,0.0007791633,0.0002386249],"category_scores_gemma":[0.0001018023,0.0008552258,0.0005366519,0.0005076018,0.0001480813,0.0000376681,0.0003802756,0.0004770641,0.0007476529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003106181,"about_ca_system_score_gemma":0.0005147449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000201541,"about_ca_topic_score_gemma":0.0001123624,"domain_scores_codex":[0.9949071,0.0005973935,0.001283902,0.001366601,0.0006313384,0.001213654],"domain_scores_gemma":[0.9978122,0.00005023701,0.0006388032,0.0008747179,0.0002526498,0.0003714109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001158204,0.0003692894,0.0009433645,0.0006277952,0.0003610104,0.00008383425,0.00004813524,0.00002526516,0.02575865,0.000002811154,0.000226365,0.9714376],"study_design_scores_gemma":[0.0004845977,0.0007986566,0.0001993663,0.003945119,0.0004306285,0.00007102693,0.00008755487,0.000003373229,0.0657509,0.00002108336,0.9269165,0.001291135],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4059451,0.5922011,6.925577e-7,0.00002072054,0.0009587784,0.0005780329,0.00008045424,0.0000268998,0.0001882092],"genre_scores_gemma":[0.03234511,0.9652025,0.00005341549,0.0002947903,0.0004462894,0.0001871723,0.001005925,0.000118933,0.0003459086],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9701465,"threshold_uncertainty_score":0.9993898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0991084384430567,"score_gpt":0.3235341073674521,"score_spread":0.2244256689243954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}