{"id":"W2333638833","doi":"10.2174/157488412800228857","title":"Polyethylenimine as a Promising Vector for Targeted siRNA Delivery","year":2012,"lang":"en","type":"review","venue":"Current Clinical Pharmacology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Polyethylenimine; Small interfering RNA; RNA interference; Transfection; Gene silencing; Gene delivery; Genetic enhancement; Viral vector; RNA; Small hairpin RNA; Chemistry; Nanotechnology; Cell biology; Biology; Materials science; Gene; Biochemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002807032,0.0006369408,0.0006878462,0.001247188,0.000163623,0.0005736828,0.0004936666,0.000764237,0.001437117],"category_scores_gemma":[0.0001299773,0.000251389,0.0002453552,0.0009115448,0.0003338365,0.0007173636,0.0002960867,0.0009504877,0.001410555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000461625,"about_ca_system_score_gemma":0.0004378093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004488028,"about_ca_topic_score_gemma":0.0006478074,"domain_scores_codex":[0.9998705,0.00001803762,0.000012432,0.0000324546,0.00005591039,0.00001071364],"domain_scores_gemma":[0.9999448,0.00002042915,0.00001252625,0.000002469497,0.00001377946,0.000005953471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007336262,0.0001404055,0.0002469673,0.008594221,0.00006967854,0.0007296582,0.00008209096,0.0007143299,0.1835297,0.00905075,0.007380666,0.7893882],"study_design_scores_gemma":[0.00002226109,0.0003765129,0.001017084,0.0006739357,0.00009314457,0.003832267,0.00003738477,0.0004712872,0.07730887,0.001987763,0.9141377,0.00004185035],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002671505,0.9866936,0.004755669,0.0002692937,0.0002611986,0.00002753693,0.00004372291,0.0000573758,0.005220185],"genre_scores_gemma":[0.01309419,0.974741,0.004228591,0.0003145587,0.0001527898,0.00005128652,0.0001276572,0.00001033381,0.00727956],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001437117,"threshold_uncertainty_score":0.004807651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2038870427969122,"score_gpt":0.5008737550898259,"score_spread":0.2969867122929137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}