{"id":"W2333651255","doi":"10.1158/1538-7445.am2011-4398","title":"Abstract 4398: MEK inhibitors prevent rebound reactivation of ERK signaling by the RAF inhibitor PLX4032 and enhance its antitumor activity","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Workplace Health, Safety and Compensation Commission","funders":"","keywords":"MAPK/ERK pathway; Melanoma; MEK inhibitor; Cancer research; Kinase; Phosphorylation; Therapeutic index; Medicine; V600E; Signal transduction; Mutant; Pharmacology; Chemistry; Biology; Drug; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001012676,0.0006274996,0.0003933674,0.0002517008,0.0001360653,0.0002454067,0.0002820927,0.000276155,0.004924375],"category_scores_gemma":[0.00009247244,0.0001664433,0.0002656555,0.0001833209,0.0001474595,0.0001834853,0.0001427944,0.001088716,0.001111112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001743058,"about_ca_system_score_gemma":0.0002642651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003851427,"about_ca_topic_score_gemma":0.0006009063,"domain_scores_codex":[0.9998796,0.00001727487,0.000009528671,0.00001403835,0.00003589669,0.000043627],"domain_scores_gemma":[0.9999307,0.00001445476,0.00001474922,0.000009111554,0.000007241179,0.00002366199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001708809,0.0005815724,0.0001976523,0.00007587441,0.00001633977,0.00007180672,0.00001243481,0.000217126,0.9889664,0.0001263651,0.0004311073,0.007594435],"study_design_scores_gemma":[0.0003618353,0.005671035,0.004426803,0.00001127705,0.00002548455,0.0003560398,0.00001110944,0.0009928836,0.9841973,0.00004743941,0.003892837,0.000005975748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911095,0.002195797,0.001094303,0.0001487951,0.00007936704,0.00009381666,0.000812789,0.0002629053,0.0042027],"genre_scores_gemma":[0.9903468,0.0009608184,0.001651594,0.00005122884,0.00002784804,0.00008329103,0.001315218,0.00004132184,0.005521832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004924375,"threshold_uncertainty_score":0.01647371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06595565880279666,"score_gpt":0.3472648796411768,"score_spread":0.2813092208383802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}