{"id":"W2333654085","doi":"10.1021/bi101767a","title":"Transmembrane Topology of Mammalian Planar Cell Polarity Protein Vangl1","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Membrane topology; Cell biology; Membrane protein; Transmembrane protein; Transmembrane domain; Intracellular; Cell polarity; Integral membrane protein; Epitope; Extracellular; Biology; Transport protein; Cell membrane; Protein domain; Topology (electrical circuits); Chemistry; Biochemistry; Membrane; Cell; Genetics; Receptor; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000585878,0.0001651689,0.00009314451,0.0001475872,0.0001384995,0.0002304988,0.0001163995,0.0001484253,0.0007627774],"category_scores_gemma":[0.0001205536,0.00007486593,0.0001334517,0.0001140878,0.0001216215,0.000175139,0.000149309,0.0002241217,0.0003558526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003591004,"about_ca_system_score_gemma":0.0001291963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007315892,"about_ca_topic_score_gemma":0.0005473812,"domain_scores_codex":[0.9999385,0.000008818237,0.000003589872,0.00001469846,0.00002096328,0.0000134259],"domain_scores_gemma":[0.999944,0.000007181655,0.00001900911,0.000004161234,0.00001137535,0.00001437424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000046089,0.000002696853,0.0004891264,0.00001037903,0.000002115326,0.00004266948,0.00001609762,0.0001165687,0.9985967,0.0001486302,0.00002372893,0.0005052079],"study_design_scores_gemma":[0.00001878124,0.0001687923,0.04065481,0.00001933692,0.0000317314,0.00136702,0.0001759081,0.006137429,0.9407097,0.0005289435,0.01016721,0.00002038542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974158,0.0003863115,0.001199049,0.00003873049,0.000005010174,0.000003966645,0.0003167462,0.00001499612,0.0006194559],"genre_scores_gemma":[0.9957873,0.0003626684,0.001546502,0.00003353286,0.000003297796,0.000007714725,0.001404466,0.00001091846,0.0008435451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007627774,"threshold_uncertainty_score":0.002605498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358739059170868,"score_gpt":0.2106910812805739,"score_spread":0.1971036906888652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}