{"id":"W2333739416","doi":"10.1038/ncomms10933","title":"Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia","year":2016,"lang":"en","type":"review","venue":"Nature Communications","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Simon Fraser University; Canadian Transplant Association; BC Cancer Agency","funders":"National Center for Advancing Translational Sciences; National Center for Chronic Disease Prevention and Health Promotion; National Institute of Environmental Health Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Agència de Gestió d'Ajuts Universitaris i de Recerca; Cancer Council NSW; Medical Research Council; University of Texas MD Anderson Cancer Center; Institut National Du Cancer; Centers for Disease Control and Prevention; National Institutes of Health; Leukemia and Lymphoma Research; National Health and Medical Research Council; University at Buffalo; Regione Autonoma della Sardegna; Associazione Italiana per la Ricerca sul Cancro; University of Pittsburgh; Stockholms Läns Landsting; University of Utah; Fondation de France; Generalitat de Catalunya; Canadian Institutes of Health Research; Bundesamt für Strahlenschutz; MedStar Health Research Institute; Cancerfonden; Bundesministerium für Bildung und Forschung; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Instituto de Salud Carlos III; Wake Forest University; Ohio State University; National Natural Science Foundation of China; U.S. Department of Health and Human Services; University of California, San Francisco; Michael Smith Health Research BC; University of Sydney; Division of Cancer Prevention, National Cancer Institute; Health Research Board; National Cancer Research Institute; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Huntsman Cancer Institute; José Carreras Leukämie-Stiftung; Yale University; Karolinska Institutet; Utah State University; World Health Organization; University of Southern California; Cancer Research UK; American Cancer Society; National Human Genome Research Institute; Cancer Council Victoria; Compagnia di San Paolo; U.S. Department of Veterans Affairs; European Commission; Utah Department of Health; Brigham and Women's Hospital; Memorial Sloan-Kettering Cancer Center","keywords":"Chronic lymphocytic leukemia; Genome-wide association study; Genetics; Locus (genetics); Biology; SNP; Genetic association; Leukemia; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001698444,0.0006256473,0.006674579,0.00112902,0.0002956451,0.0000359536,0.001907932,0.001342371,0.00009976758],"category_scores_gemma":[0.01121337,0.0004074009,0.006336831,0.002239708,0.0003824715,0.0001293152,0.0009052631,0.001228634,0.00005644405],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.2822855,"about_ca_system_score_gemma":0.04413089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001469109,"about_ca_topic_score_gemma":0.001138782,"domain_scores_codex":[0.9955596,0.000621247,0.00157334,0.0006816973,0.0009450399,0.0006190864],"domain_scores_gemma":[0.9639736,0.02765817,0.001692276,0.005174375,0.001332049,0.0001695545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004079036,0.00009036509,0.00002588786,0.01479711,0.9541322,0.000004041109,0.0002502374,0.0001507436,0.000001903754,0.0005427368,0.0104348,0.0195292],"study_design_scores_gemma":[0.001880521,0.0000495721,0.000006034054,0.0006107457,0.3943454,0.000003715012,0.00003197421,0.001022413,0.000002123808,0.000017196,0.6018087,0.0002216391],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000005791525,0.9940857,0.0001184275,0.0007009552,0.000102292,0.002998589,0.001579891,0.00007336002,0.0003350016],"genre_scores_gemma":[0.001519161,0.9872735,0.001249921,0.0001858093,0.0001379501,0.001815257,0.002786803,0.0001116644,0.004919899],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5913739,"threshold_uncertainty_score":0.9999541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1872520685799256,"score_gpt":0.4446420307413979,"score_spread":0.2573899621614723,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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