{"id":"W2333751993","doi":"10.1038/sj.onc.1205861","title":"Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6−/− small intestinal epithelium","year":2002,"lang":"en","type":"article","venue":"Oncogene","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Institutes of Health; National Cancer Institute; Alberta Heritage Foundation for Medical Research; Canada Research Chairs","keywords":"Biology; DNA mismatch repair; MSH2; Lac repressor; Mutation; Mutant; Molecular biology; Mutagenesis; DNA; MSH6; Genetics; DNA repair; Gene; Cell biology; Plasmid; lac operon","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004241,0.0001033039,0.0002145515,0.0001284483,0.00001968191,0.000004325481,0.00004735209,0.00005527857,0.0001778993],"category_scores_gemma":[0.0001831206,0.00009818123,0.00002874738,0.0003154979,0.00008607926,0.0000229332,0.00001307815,0.00009003474,0.00001087027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009179555,"about_ca_system_score_gemma":0.00004445401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001445445,"about_ca_topic_score_gemma":0.0003050186,"domain_scores_codex":[0.9992272,0.00002780286,0.0002578418,0.0001968509,0.0001301057,0.0001601843],"domain_scores_gemma":[0.9995551,0.00006256039,0.00004950376,0.0001404664,0.0001094956,0.00008285476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001186137,0.0001156663,0.003186847,0.00006849828,0.00001130815,0.00003287183,0.00261217,0.0001828953,0.983991,0.00001688196,0.0000353407,0.009627938],"study_design_scores_gemma":[0.001785865,0.001505885,0.04206806,0.0004285943,0.00007522995,0.0002301395,0.0003561947,0.002848044,0.9499185,0.0002395565,0.0003570654,0.0001868627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966335,0.0005364158,0.000682632,0.0008043171,0.0000667022,0.0003940896,0.00002519943,0.00001923029,0.0008378869],"genre_scores_gemma":[0.9888765,0.00007885646,0.01063064,0.0001719792,0.00003218953,0.00004763974,0.000006690341,0.00001379781,0.0001417493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03888122,"threshold_uncertainty_score":0.4003714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03141946287965162,"score_gpt":0.2568711520023839,"score_spread":0.2254516891227323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}