{"id":"W2333780672","doi":"10.1158/1538-7445.am10-lb-374","title":"Abstract LB-374: The Hh inhibitor IPI-926 enhances tumor perfusion and nab-paclitaxel activity in a pancreatic xenograft model","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"FujiFilm VisualSonics (Canada); Illumisonics (Canada)","funders":"","keywords":"Paclitaxel; Gemcitabine; Pancreatic cancer; Cancer research; Medicine; Cancer; Stroma; Hedgehog; Pancreas; Internal medicine; Chemistry; Immunohistochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001239692,0.0001664821,0.0001876599,0.00008826057,0.0003151959,0.00006626742,0.0002749874,0.0001295321,0.00002642451],"category_scores_gemma":[0.0004010577,0.0001192456,0.00005140425,0.0001981235,0.000507161,0.00001033497,0.0003190334,0.0006949108,0.000007971853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003753966,"about_ca_system_score_gemma":0.0003220201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006486655,"about_ca_topic_score_gemma":0.002625224,"domain_scores_codex":[0.9983537,0.0001294984,0.0001697533,0.0004791679,0.0003535289,0.0005143187],"domain_scores_gemma":[0.9991453,0.0001162349,0.00004795217,0.0004013081,0.0001825015,0.0001066816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001422375,0.00005814313,0.003254332,0.00005989835,0.00001666132,0.000005598021,0.0004604008,0.00003291763,0.9922878,0.00001173341,0.0006231967,0.003047098],"study_design_scores_gemma":[0.0004831222,0.0001510881,0.01992106,0.00008425919,0.000007169679,0.000004092541,0.0004088116,0.000590193,0.9752811,0.0001689244,0.002698191,0.0002019583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963476,0.001862327,0.0000220717,0.0007106947,0.0001148925,0.0003946158,0.00003167191,0.00001005506,0.0005060766],"genre_scores_gemma":[0.9977605,0.0009681878,0.00008426938,0.00006644093,0.0003720101,0.0002874682,0.000004881152,0.00002519888,0.0004310428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01700665,"threshold_uncertainty_score":0.4862694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04810510645222769,"score_gpt":0.3744452486785315,"score_spread":0.3263401422263038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}