{"id":"W2333830073","doi":"10.1038/sj.cgt.7700326","title":"Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line","year":2001,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Inimex Pharmaceuticals (Canada)","funders":"Fondazione Italiana per la Ricerca sul Cancro; Associazione Italiana per la Ricerca sul Cancro","keywords":"Melanoma; In vivo; Chemistry; Antisense therapy; Pharmacology; Liposome; Cancer research; Molecular biology; Medicine; Biology; Biochemistry; Oligonucleotide; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139053,0.0001366548,0.0002126866,0.0001220547,0.00001698742,0.00001019532,0.0001363296,0.00008963819,0.00003872357],"category_scores_gemma":[0.00001051001,0.000132569,0.00005324454,0.0002029693,0.00005739403,0.00001020972,0.00002817991,0.00006721592,0.000001219015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002467443,"about_ca_system_score_gemma":0.00005332749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010617,"about_ca_topic_score_gemma":0.002390351,"domain_scores_codex":[0.9990192,0.00006041031,0.0003393917,0.0002756585,0.00007278539,0.0002325683],"domain_scores_gemma":[0.9996127,0.000007139014,0.00008827689,0.0002202065,0.00003993014,0.00003167665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003208724,0.0001818686,0.1192475,0.00000596111,0.00001279237,0.00001130375,0.0002196814,0.0009945375,0.8704424,0.000006698438,0.00003112335,0.008525273],"study_design_scores_gemma":[0.001511853,0.0003427741,0.1967394,0.00004081572,0.000002043469,0.000002500167,0.0000444289,0.0002982963,0.8006276,0.00004102899,0.0002225768,0.0001267203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967576,0.002813043,0.00001374101,0.00007178846,0.00007749941,0.000197283,0.000009382564,0.000005172622,0.00005454003],"genre_scores_gemma":[0.9934364,0.006098426,0.00006412819,0.0001196939,0.0001646621,0.00002574515,0.0000168213,0.00001601374,0.000058098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07749184,"threshold_uncertainty_score":0.5406007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02395662836712133,"score_gpt":0.3001834513273878,"score_spread":0.2762268229602665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}