{"id":"W2333907568","doi":"10.1021/jp3072553","title":"A New Amphipathic, Amino-Acid-Pairing (AAP) Peptide as siRNA Delivery Carrier: Physicochemical Characterization and in Vitro Uptake","year":2012,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Small interfering RNA; Isothermal titration calorimetry; Peptide; Biophysics; Chemistry; Amphiphile; Amino acid; Fluorescence; Fluorescence microscope; Biochemistry; Dynamic light scattering; In vitro; RNA; Biology; Materials science; Nanotechnology; Nanoparticle; Organic chemistry; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001880706,0.0001790445,0.0002288351,0.00001714874,0.00004580705,0.00002256064,0.0002342343,0.0001025421,0.00001310834],"category_scores_gemma":[0.00006883856,0.0001375112,0.0001260953,0.00007268784,0.00007892305,0.00002934218,0.0001111491,0.0002887705,0.000005057779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002713384,"about_ca_system_score_gemma":0.00008165222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001231701,"about_ca_topic_score_gemma":6.506988e-7,"domain_scores_codex":[0.9990966,0.00004202177,0.000271293,0.0001341652,0.0001859494,0.0002700052],"domain_scores_gemma":[0.9993061,0.00002393864,0.0002050213,0.0001964031,0.0000837156,0.0001848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004637724,0.00008366766,0.0002782038,0.00002229333,0.00004318206,0.00000306115,0.0003815338,0.0000090986,0.9950426,0.000001571505,0.0001188176,0.003552197],"study_design_scores_gemma":[0.0004134156,0.00008845509,0.002324304,0.00004432525,0.00004790345,0.0001053541,0.0001602287,0.00008252844,0.9955441,0.00003364328,0.001004019,0.0001516802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988019,0.0005246027,0.0002956785,0.0001023606,0.00004805933,0.00004778639,0.000009478145,0.000003905089,0.0001662153],"genre_scores_gemma":[0.9975599,0.0001631507,0.00005439762,0.0001458391,0.001785175,0.000001878434,0.00002942254,0.00001729349,0.000242959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003400516,"threshold_uncertainty_score":0.5607542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009208458247948246,"score_gpt":0.2373578103658303,"score_spread":0.2281493521178821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}