{"id":"W2333907568","doi":"10.1021/jp3072553","title":"A New Amphipathic, Amino-Acid-Pairing (AAP) Peptide as siRNA Delivery Carrier: Physicochemical Characterization and in Vitro Uptake","year":2012,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Small interfering RNA; Isothermal titration calorimetry; Peptide; Biophysics; Chemistry; Amphiphile; Amino acid; Fluorescence; Fluorescence microscope; Biochemistry; Dynamic light scattering; In vitro; RNA; Biology; Materials science; Nanotechnology; Nanoparticle; Organic chemistry; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002482968,0.0004031751,0.0002706778,0.0002542768,0.0002088757,0.0002692437,0.0002687753,0.0005250078,0.0003234112],"category_scores_gemma":[0.0002904257,0.0001338009,0.0001455909,0.0002041404,0.0002231303,0.0003950248,0.0001798938,0.0004305551,0.000290204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372608,"about_ca_system_score_gemma":0.0002206335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003330847,"about_ca_topic_score_gemma":0.0002568805,"domain_scores_codex":[0.9998406,0.00002487442,0.000017529,0.00003678902,0.00006642067,0.00001379199],"domain_scores_gemma":[0.9998368,0.00002910609,0.00003601132,0.00001112434,0.0000472937,0.00003964412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002690019,0.0000122515,0.00005121806,0.00002790784,0.000001611994,0.00003602758,0.000006478421,0.0000722183,0.9982907,0.00004923634,0.00001285277,0.001412518],"study_design_scores_gemma":[0.000005959085,0.0001953487,0.0005306964,0.000002920477,0.000005669954,0.0003064524,0.000003466244,0.001165889,0.9957275,0.00002222913,0.002028039,0.000005735876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682113,0.005174231,0.02426536,0.0001607717,0.00004253011,0.0002126061,0.0002655828,0.0001299354,0.001537681],"genre_scores_gemma":[0.9416792,0.003893881,0.04927093,0.0001288099,0.00003137728,0.000195124,0.0007803403,0.00005481828,0.003965454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005250078,"threshold_uncertainty_score":0.001721442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009208458247948246,"score_gpt":0.2373578103658303,"score_spread":0.2281493521178821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}