{"id":"W2333948856","doi":"10.1093/neuonc/nov061.94","title":"MB-18 * POST-TRANSLATIONAL REGULATION OF ATOH1: FROM CEREBELLAR DEVELOPMENT TO MEDULLOBLASTOMA FORMATION","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Sonic hedgehog; Transcription factor; Medulloblastoma; Cerebellum; Biology; Ubiquitin ligase; GLI2; Cell biology; Cancer research; Genetics; Ubiquitin; Signal transduction; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002241857,0.0001425009,0.0002050342,0.00007699471,0.00005954886,0.00000629008,0.0001451827,0.0001850016,0.00002852823],"category_scores_gemma":[0.0002724726,0.0001459154,0.00004813884,0.0001043534,0.00005289501,0.000007798845,0.0001025164,0.00006886212,0.0000621493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006128438,"about_ca_system_score_gemma":0.0003882697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001678997,"about_ca_topic_score_gemma":0.0001238814,"domain_scores_codex":[0.9987841,0.000128081,0.000385957,0.0002844056,0.0002239979,0.0001934103],"domain_scores_gemma":[0.9990848,0.00005881213,0.0001452293,0.0001978292,0.000385128,0.0001282466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002799798,0.00006060506,0.001038414,0.000008483181,0.00003718306,0.000002882677,0.001424429,0.0007264378,0.9863201,0.00002460159,0.002970726,0.007106157],"study_design_scores_gemma":[0.0007639572,0.000680968,0.003720757,0.000007598239,0.00001721523,0.00001519238,0.0001597025,0.0001092302,0.7838324,0.0000904341,0.2104642,0.000138327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895387,0.0001545138,0.006754956,0.0009911852,0.0003449595,0.000275518,0.00004916523,0.00002008517,0.00187088],"genre_scores_gemma":[0.9906271,0.000007899886,0.008057958,0.0006389737,0.0001932776,0.00002943514,0.0003932375,0.00001895128,0.00003312967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2074935,"threshold_uncertainty_score":0.5950257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03505896558823104,"score_gpt":0.2847212438276898,"score_spread":0.2496622782394587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}