{"id":"W2333948856","doi":"10.1093/neuonc/nov061.94","title":"MB-18 * POST-TRANSLATIONAL REGULATION OF ATOH1: FROM CEREBELLAR DEVELOPMENT TO MEDULLOBLASTOMA FORMATION","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Sonic hedgehog; Transcription factor; Medulloblastoma; Cerebellum; Biology; Ubiquitin ligase; GLI2; Cell biology; Cancer research; Genetics; Ubiquitin; Signal transduction; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006211361,0.0002033356,0.0001185058,0.0001699315,0.0001670288,0.0002738566,0.0001606737,0.0001352333,0.0008029014],"category_scores_gemma":[0.0000600516,0.00008274344,0.0001615985,0.000101492,0.0001408333,0.0001997722,0.000158401,0.0002011861,0.0003382076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003499385,"about_ca_system_score_gemma":0.000134375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009617543,"about_ca_topic_score_gemma":0.001235521,"domain_scores_codex":[0.9999498,0.000004346869,0.00000345473,0.0000160531,0.00001051928,0.00001582465],"domain_scores_gemma":[0.999956,0.000003263546,0.0000159662,0.000003131859,0.000005965724,0.00001569521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001256699,0.00001030797,0.0008376028,0.00003387308,0.000004298224,0.0001092542,0.00001546998,0.00002843458,0.9965676,0.0002097908,0.00004753348,0.002010087],"study_design_scores_gemma":[0.000006171034,0.0001141261,0.02751736,0.00000648228,0.00001695571,0.0003063987,0.00002858581,0.000335175,0.9658391,0.00007487578,0.005751491,0.000003290107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895988,0.005368576,0.002701156,0.0001056914,0.00003147667,0.00001661363,0.0004490169,0.00006538614,0.001663372],"genre_scores_gemma":[0.9932998,0.001842355,0.001451768,0.00003653811,0.00001097903,0.000011926,0.0005362874,0.00001602965,0.002794131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009617543,"threshold_uncertainty_score":0.002685964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03505896558823104,"score_gpt":0.2847212438276898,"score_spread":0.2496622782394587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}