{"id":"W2334064455","doi":"10.1021/acs.jproteome.6b00074","title":"Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic <i>Escherichia coli</i> Type III Secretion System Effectors","year":2016,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canadian Association of Gastroenterology","keywords":"Effector; Biology; Secretion; Stable isotope labeling by amino acids in cell culture; Intracellular; Virulence; Cell biology; Intracellular parasite; Quantitative proteomics; Microtubule; Mutant; Escherichia coli; Proteomics; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005438767,0.000204195,0.0003867085,0.0004250798,0.0003189071,0.0001016832,0.0004722389,0.0001786293,0.00001181404],"category_scores_gemma":[0.003204868,0.000137237,0.000232745,0.000739519,0.0002979282,0.00003311459,0.0002076364,0.0003924288,0.00001784947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000289879,"about_ca_system_score_gemma":0.0005167867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009594396,"about_ca_topic_score_gemma":0.000009151109,"domain_scores_codex":[0.9969198,0.0005056179,0.0005122843,0.0003570302,0.0009769084,0.0007283225],"domain_scores_gemma":[0.9967455,0.0004587644,0.0003299104,0.0002888562,0.001953968,0.0002229969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001730397,0.00006701515,0.0008349452,0.0003112386,0.0003428563,0.00001464633,0.00006083322,0.000002322402,0.9951633,0.0003307408,0.001084329,0.00005734969],"study_design_scores_gemma":[0.003287893,0.007682719,0.002500293,0.000669824,0.00004802261,0.00003947894,0.001707662,0.0001126948,0.9803069,0.00009719044,0.00321338,0.0003339048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713345,0.001164815,0.02532316,0.0003975777,0.000306726,0.00121449,0.00004361701,0.00001052875,0.0002046483],"genre_scores_gemma":[0.9884562,0.0006637877,0.008916875,0.000008644091,0.0005307845,0.0001633282,0.000006997417,0.00004971959,0.001203604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01712183,"threshold_uncertainty_score":0.5596362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0626545562492794,"score_gpt":0.3865354479597937,"score_spread":0.3238808917105143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}