{"id":"W2334087039","doi":"10.1158/1535-7163.targ-11-c143","title":"Abstract C143: Combining siRNAs targeting thymidylate synthase and thymidine kinase 1 or 2 sensitizes human tumor cells to 5FUdR and pemetrexed.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Thymidylate synthase; Thymidine kinase; Cancer research; Gene knockdown; Small interfering RNA; Downregulation and upregulation; Pemetrexed; Cancer cell; Kinase; Cancer; Biology; Chemistry; Pharmacology; Molecular biology; Transfection; Cell culture; Apoptosis; Cell biology; Cisplatin; Biochemistry; Immunology; Chemotherapy; Fluorouracil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479806,0.0004897778,0.0004365418,0.0002323261,0.0001750483,0.0002751915,0.000247042,0.0005397919,0.004924461],"category_scores_gemma":[0.0001306921,0.0001379908,0.0003955,0.0001721827,0.0001852786,0.000128443,0.0001419301,0.0005619877,0.0009442825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003564381,"about_ca_system_score_gemma":0.0003722803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002197965,"about_ca_topic_score_gemma":0.002043697,"domain_scores_codex":[0.9998117,0.00002021984,0.0000207088,0.00005439853,0.00004931559,0.00004363614],"domain_scores_gemma":[0.9999107,0.00002678594,0.00001187005,0.00001208288,0.00001249346,0.00002593376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001931213,0.0000618984,0.00006461934,0.000041616,0.000009071872,0.00003492763,0.000009238314,0.00007512434,0.9980076,0.00006066947,0.0001938796,0.001248319],"study_design_scores_gemma":[0.00003548429,0.0006190411,0.001199099,0.000003074312,0.00001601116,0.00008555633,0.000007172751,0.0004941549,0.9956297,0.00001035871,0.001897186,0.000003168884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821758,0.002702804,0.00347787,0.0002466624,0.0002520316,0.0002838013,0.002031831,0.000308067,0.008521119],"genre_scores_gemma":[0.9825545,0.0008189667,0.004181915,0.0001609493,0.00003413266,0.0002451002,0.002919865,0.00005445906,0.009030133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004924461,"threshold_uncertainty_score":0.01647389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05268298062534472,"score_gpt":0.3000176279460013,"score_spread":0.2473346473206566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}