{"id":"W2334136769","doi":"10.1007/s00213-016-4277-y","title":"A comparison of novel, selective fatty acid amide hydrolase (FAAH), monoacyglycerol lipase (MAGL) or dual FAAH/MAGL inhibitors to suppress acute and anticipatory nausea in rat models","year":2016,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Nausea and vomiting management","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Institute of Neurosciences, Mental Health and Addiction; National Institute on Drug Abuse; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Monoacylglycerol lipase; Fatty acid amide hydrolase; Nausea; Pharmacology; Anandamide; IC50; Endocannabinoid system; Chemistry; Medicine; Biochemistry; Cannabinoid receptor; In vitro; Anesthesia; Antagonist; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003038823,0.0006288053,0.0007097691,0.0004549322,0.0002466106,0.00032742,0.0005284612,0.0005185261,0.001495404],"category_scores_gemma":[0.000227117,0.0002361027,0.0005781775,0.0002242046,0.0004504338,0.0008906191,0.000183742,0.001405962,0.0002511595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003838902,"about_ca_system_score_gemma":0.0006687938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007777657,"about_ca_topic_score_gemma":0.002096785,"domain_scores_codex":[0.9998759,0.00001367319,0.00001245578,0.00003380367,0.00002143342,0.00004278869],"domain_scores_gemma":[0.9998665,0.00001882226,0.00002765076,0.00001556041,0.00001885152,0.00005256919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01820016,0.003198714,0.0003259817,0.0005288565,0.0001210289,0.0001434185,0.00005656782,0.000282493,0.9515324,0.0005747111,0.0004236547,0.02461205],"study_design_scores_gemma":[0.001819347,0.03804314,0.002008801,0.00003647549,0.0003459045,0.0004587755,0.00009309051,0.001407656,0.9508731,0.0002148038,0.004664697,0.00003424719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871982,0.006353741,0.003693048,0.0003757561,0.0002603151,0.0001597373,0.0004192781,0.0001344919,0.001405493],"genre_scores_gemma":[0.980063,0.00809475,0.005852719,0.0001980312,0.00009584302,0.0003248958,0.0006972706,0.00002147974,0.004652014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001495404,"threshold_uncertainty_score":0.005002558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05848797709549376,"score_gpt":0.3998674874120958,"score_spread":0.341379510316602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}