{"id":"W2334175582","doi":"10.1021/mp500429u","title":"Design and Evaluation of Endosomolytic Biocompatible Peptides as Carriers for siRNA Delivery","year":2014,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Shanghai Municipal Education Commission; Canada Research Chairs","keywords":"Small interfering RNA; RNA interference; Transfection; In vivo; Peptide; In vitro; Cytotoxicity; Gene silencing; Chemistry; Cell biology; Gene delivery; RNA; Cancer research; Biology; Biochemistry; Gene; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003725068,0.0004778006,0.0002506977,0.000263165,0.0001492038,0.000341519,0.0002523382,0.0004219092,0.0003861906],"category_scores_gemma":[0.0002920038,0.0001423911,0.00019871,0.000163728,0.0001900216,0.0003111597,0.0001739124,0.0002904855,0.0002753038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074363,"about_ca_system_score_gemma":0.0002746544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003571303,"about_ca_topic_score_gemma":0.000253251,"domain_scores_codex":[0.9998323,0.00003752414,0.00001807139,0.00003151631,0.00005495032,0.00002555747],"domain_scores_gemma":[0.9998517,0.00002279937,0.00004494888,0.000009820469,0.00003868508,0.00003198889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008030464,0.0000563943,0.00006833453,0.00006838714,0.000005162676,0.00006907801,0.00001891346,0.0006462266,0.9953755,0.0001901377,0.00001923894,0.003402194],"study_design_scores_gemma":[0.00002455183,0.0005553488,0.0003575355,0.000004572332,0.00001157773,0.00009140888,0.000006563525,0.001531479,0.9958366,0.00002843026,0.001545038,0.000006749675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753975,0.002749202,0.01978608,0.00009579446,0.00003410755,0.0003115805,0.0001357401,0.00006671237,0.001423189],"genre_scores_gemma":[0.96505,0.0024474,0.0292915,0.00007587719,0.00001718153,0.0002576314,0.0002852058,0.00003236306,0.00254296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004778006,"threshold_uncertainty_score":0.002230644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04688835194862433,"score_gpt":0.3392684286284161,"score_spread":0.2923800766797918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}