{"id":"W2334175582","doi":"10.1021/mp500429u","title":"Design and Evaluation of Endosomolytic Biocompatible Peptides as Carriers for siRNA Delivery","year":2014,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Shanghai Municipal Education Commission; Canada Research Chairs","keywords":"Small interfering RNA; RNA interference; Transfection; In vivo; Peptide; In vitro; Cytotoxicity; Gene silencing; Chemistry; Cell biology; Gene delivery; RNA; Cancer research; Biology; Biochemistry; Gene; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006931734,0.0001531093,0.0001506434,0.00006017503,0.00005502905,0.00001913952,0.0001411428,0.00009509965,0.000009785669],"category_scores_gemma":[0.0001331022,0.0001586426,0.00008026243,0.00005889498,0.00008489258,0.000005300491,0.00005890804,0.00005247934,0.000003570521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000142246,"about_ca_system_score_gemma":0.0001084475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001049901,"about_ca_topic_score_gemma":0.000001578929,"domain_scores_codex":[0.9989026,0.0001878905,0.000206186,0.0002813867,0.0002206811,0.000201304],"domain_scores_gemma":[0.999194,0.00003586047,0.00009938629,0.0002295528,0.0003530571,0.00008816036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001211217,0.00003101188,0.0001465551,0.00003952412,0.000103279,6.651216e-7,0.00005997547,0.005087433,0.9788858,0.00006148667,0.000234347,0.0152288],"study_design_scores_gemma":[0.001255045,0.0004703234,0.00003254265,0.00001937662,0.0002199379,0.00000910784,0.0000507509,0.06188064,0.9327888,0.000469703,0.002637943,0.0001657714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9315354,0.001845568,0.06559557,0.00004343444,0.0000965529,0.0005599262,0.000009399583,0.00000732134,0.0003068007],"genre_scores_gemma":[0.9955247,0.0002497043,0.003592142,0.0003952682,0.00005329492,0.00006129683,0.00004945261,0.00002369422,0.00005047137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06398925,"threshold_uncertainty_score":0.6469258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04688835194862433,"score_gpt":0.3392684286284161,"score_spread":0.2923800766797918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}