{"id":"W2334273673","doi":"10.1021/ja109192w","title":"Stereo- and Regioselective Gold-Catalyzed Hydroamination of Internal Alkynes with Dialkylamines","year":2010,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Catalytic Alkyne Reactions","field":"Chemistry","cited_by":176,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Chemistry; Hydroamination; Regioselectivity; Alkyne; Amine gas treating; Nitrile; Ether; Amide; Organic chemistry; Ligand (biochemistry); Aryl; Catalysis; Combinatorial chemistry; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740272,0.0003385901,0.0001297974,0.0001020292,0.0001030755,0.0001891142,0.000315494,0.0001916147,0.0004551608],"category_scores_gemma":[0.0002161833,0.0001335332,0.000145435,0.00006454301,0.0002204287,0.0002694961,0.0003297121,0.0003505549,0.0002932179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002038992,"about_ca_system_score_gemma":0.0001657907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003921384,"about_ca_topic_score_gemma":0.001258326,"domain_scores_codex":[0.9998847,0.00001505373,0.0000138212,0.00002876055,0.00003072733,0.00002688952],"domain_scores_gemma":[0.9999157,0.00001433271,0.00002193845,0.00001835922,0.0000152048,0.00001439938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003600592,0.00001485009,0.0001293699,0.00005866635,0.000006345805,0.0001385736,0.00004529301,0.0001491803,0.9944134,0.0003594122,0.00006738721,0.004581457],"study_design_scores_gemma":[0.000004003936,0.00005066711,0.0001809287,0.000001228117,0.000003298279,0.0001030027,0.000007818175,0.0002023946,0.9985568,0.00002439907,0.0008632253,0.000002161826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803023,0.0007827843,0.01241055,0.00009246417,0.00004342802,0.00004867977,0.0001168128,0.0001510681,0.00605181],"genre_scores_gemma":[0.9914758,0.0004688353,0.005824639,0.00002053475,0.00000738738,0.00001099657,0.00008459135,0.00002216052,0.002085087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004551608,"threshold_uncertainty_score":0.00152272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004858505917926976,"score_gpt":0.2279511534675889,"score_spread":0.2230926475496619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}