{"id":"W2334301577","doi":"10.1021/tx5001333","title":"Activation of Inflammasomes by Agents Causing Idiosyncratic Skin Reactions: A Possible Biomarker","year":2014,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Telaprevir; Boceprevir; Inflammasome; Chemistry; Drug; Immune system; Dimethyl fumarate; Pharmacology; Biochemistry; Immunology; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009537109,0.0001163841,0.0001848842,0.0001880759,0.00006058765,0.00001501993,0.0001933645,0.0003134838,0.00005455974],"category_scores_gemma":[0.00150065,0.0001168085,0.00005904636,0.000358099,0.0003000062,0.00001165614,0.0001726574,0.0002622242,0.00001029355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005940301,"about_ca_system_score_gemma":0.0001084111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000050348,"about_ca_topic_score_gemma":0.00001127804,"domain_scores_codex":[0.9983553,0.0003023244,0.0003499678,0.0003198683,0.000222693,0.0004498661],"domain_scores_gemma":[0.9992299,0.0001586106,0.00008068037,0.0003171081,0.0001451274,0.00006853978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001554388,0.0001372861,0.001169211,0.00005406553,0.00002687143,0.000001020497,0.00004083999,0.000008833438,0.9902676,0.0001131078,0.002959927,0.005065845],"study_design_scores_gemma":[0.0007044009,0.0001870614,0.001519633,0.00003994979,0.00000272213,0.000003998338,0.00009948156,0.0003450118,0.97699,0.0006332908,0.01936044,0.0001140052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956595,0.0001747431,0.0001662657,0.000539272,0.00004832726,0.0002173355,0.000002757671,0.00000581558,0.003185957],"genre_scores_gemma":[0.9990489,0.0001494368,0.0001317413,0.00008675855,0.00005161355,0.00006237612,0.0001079904,0.00001762985,0.0003435743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01640051,"threshold_uncertainty_score":0.4763314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04152067948215715,"score_gpt":0.3571038871463807,"score_spread":0.3155832076642236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}