{"id":"W2334301577","doi":"10.1021/tx5001333","title":"Activation of Inflammasomes by Agents Causing Idiosyncratic Skin Reactions: A Possible Biomarker","year":2014,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Telaprevir; Boceprevir; Inflammasome; Chemistry; Drug; Immune system; Dimethyl fumarate; Pharmacology; Biochemistry; Immunology; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001036,0.0005419711,0.0005537659,0.0008817729,0.0002210104,0.0005890578,0.0002711288,0.0006895159,0.001608188],"category_scores_gemma":[0.0007596246,0.0002351118,0.0004576365,0.0004973661,0.0004144907,0.000801283,0.000385448,0.0004793518,0.0002098693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001936104,"about_ca_system_score_gemma":0.0001431592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008936629,"about_ca_topic_score_gemma":0.00009893861,"domain_scores_codex":[0.9992914,0.0002891713,0.00009419389,0.0001164896,0.0001250032,0.00008368802],"domain_scores_gemma":[0.9993947,0.0001009221,0.0003109442,0.00005601809,0.00006958067,0.00006785549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009840488,0.0001911701,0.02558672,0.0004202157,0.0001505639,0.001226632,0.0001116011,0.0002175212,0.9624804,0.0005000546,0.00007107945,0.008059997],"study_design_scores_gemma":[0.0001227589,0.004424585,0.09754393,0.0001038094,0.0002832147,0.008273157,0.0004292817,0.00198438,0.8807303,0.001280048,0.004781743,0.00004287623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744158,0.01226581,0.01040278,0.0003260783,0.00009906045,0.0002066138,0.0002885048,0.00005105375,0.001944314],"genre_scores_gemma":[0.9926126,0.002018828,0.004368837,0.0002056996,0.00004886739,0.0000706194,0.0001432246,0.000005542264,0.0005257464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608188,"threshold_uncertainty_score":0.005478978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04152067948215715,"score_gpt":0.3571038871463807,"score_spread":0.3155832076642236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}