{"id":"W2334348255","doi":"10.1055/s-0032-1323742","title":"Energy Depletion of Bovine Mammary Epithelial Cells Activates AMPK and Suppresses Protein Synthesis Through Inhibition of mTORC1 Signaling","year":2012,"lang":"en","type":"article","venue":"Hormone and Metabolic Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Ribosomal protein s6; mTORC1; AMPK; Phosphorylation; PI3K/AKT/mTOR pathway; Protein kinase A; Cell biology; Signal transduction; P70-S6 Kinase 1; AMP-activated protein kinase; Chemistry; Endocrinology; Internal medicine; Biology; Protein phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000112215,0.0002865102,0.0004615654,0.0001792088,0.0001641089,0.0003870722,0.000168142,0.0002025593,0.000759016],"category_scores_gemma":[0.00006729909,0.0001389556,0.0002543258,0.0002058596,0.0001757167,0.000177361,0.0002085422,0.0003753965,0.0002808358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003475712,"about_ca_system_score_gemma":0.0002086961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000984906,"about_ca_topic_score_gemma":0.00183656,"domain_scores_codex":[0.9998267,0.00002894406,0.00001781169,0.00003898528,0.00004115947,0.00004648286],"domain_scores_gemma":[0.9999492,0.000008906178,0.00001822689,0.000006860195,0.000006962415,0.000009831041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001319576,0.00001576195,0.0001608171,0.00004483932,0.000004517753,0.00002785244,0.000007959883,0.00002715884,0.9988489,0.00002722889,0.00003677791,0.0006662384],"study_design_scores_gemma":[0.00002043452,0.0003691483,0.01377732,0.00001027601,0.00001844545,0.0001809103,0.00006612392,0.0006344189,0.9797492,0.00004088176,0.005126275,0.000006484969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847999,0.01127427,0.001528254,0.0002344054,0.00006425594,0.00001865667,0.000627914,0.00006191844,0.001390587],"genre_scores_gemma":[0.9923458,0.003637527,0.001301265,0.0001210112,0.0000178873,0.00004117512,0.0008526556,0.00001687719,0.001665873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000984906,"threshold_uncertainty_score":0.002539098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03068726310752028,"score_gpt":0.2991127093885523,"score_spread":0.268425446281032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}