{"id":"W2334372648","doi":"10.1042/bst0390443","title":"Signalling by amino acid nutrients","year":2011,"lang":"en","type":"review","venue":"Biochemical Society Transactions","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Cancer Research UK","keywords":"MAP kinase kinase kinase; mTORC1; Mitogen-activated protein kinase kinase; MAPK/ERK pathway; Protein kinase A; Cell biology; c-Raf; Kinase; Protein phosphatase 2; ASK1; MAP2K7; P70-S6 Kinase 1; Cyclin-dependent kinase 9; Biochemistry; Activator (genetics); Biology; Chemistry; Cyclin-dependent kinase 2; Phosphatase; Signal transduction; Phosphorylation; Protein kinase B","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004205343,0.001268709,0.001551509,0.001930249,0.0003431665,0.001123673,0.0009364978,0.001233647,0.002368118],"category_scores_gemma":[0.0003360605,0.0004119162,0.0003812703,0.001811965,0.0006742104,0.001433323,0.0008393676,0.002018016,0.004278034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001075111,"about_ca_system_score_gemma":0.0006153812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007505228,"about_ca_topic_score_gemma":0.001152621,"domain_scores_codex":[0.9998186,0.0000278486,0.00002717507,0.00003658361,0.00006842394,0.00002143105],"domain_scores_gemma":[0.9998598,0.00004698661,0.00001930384,0.000007061506,0.0000445261,0.00002219821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001547238,0.00007367798,0.0001623799,0.01084943,0.0001090352,0.0003838689,0.00007710406,0.0005565363,0.01061989,0.006228941,0.04293133,0.927853],"study_design_scores_gemma":[0.00001665767,0.00004921198,0.0005352987,0.0008632052,0.00003640696,0.000997444,0.00003042936,0.00006986706,0.001355123,0.001810633,0.9942205,0.00001521974],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001712707,0.9973933,0.0001600611,0.0002265323,0.000374115,0.000004032636,0.00001779235,0.00001215596,0.001640844],"genre_scores_gemma":[0.0008534559,0.997218,0.0001660757,0.0002013784,0.0002201547,0.000008269004,0.00003324682,0.000001926362,0.00129749],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002368118,"threshold_uncertainty_score":0.007922173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03193139553439445,"score_gpt":0.2936924548517468,"score_spread":0.2617610593173523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}