{"id":"W2334400532","doi":"10.1158/1538-7445.am2012-1444","title":"Abstract 1444: Stathmin suppression influences ROCK signaling and reduces cell invasion and metastasis in neuroblastoma","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Stathmin; Cofilin; Neuroblastoma; Biology; ROCK2; Metastasis; Cancer research; Transfection; Cell migration; Small hairpin RNA; Cell biology; Kinase; Cytoskeleton; Molecular biology; Microtubule; Actin cytoskeleton; Cell; Cancer; Cell culture; Rho-associated protein kinase; Gene knockdown","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137287,0.0002382873,0.0003253437,0.0002250875,0.0001737874,0.0002264637,0.0001836499,0.0002793806,0.00330077],"category_scores_gemma":[0.00006959852,0.00009985211,0.0002628335,0.0001864502,0.0002375662,0.0001448738,0.0001322931,0.0005646507,0.0006191593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003347745,"about_ca_system_score_gemma":0.0003327403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001392248,"about_ca_topic_score_gemma":0.00356924,"domain_scores_codex":[0.9998523,0.00001619265,0.00001729484,0.00002781259,0.00005282142,0.00003352958],"domain_scores_gemma":[0.9999442,0.000006974768,0.00001512673,0.000005871188,0.000008176959,0.00001957537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002103615,0.00004100014,0.0002437798,0.00006921286,0.000006570341,0.00003681558,0.00001538321,0.0000712203,0.9976848,0.00008160045,0.0001970633,0.001342108],"study_design_scores_gemma":[0.00004961733,0.0006326215,0.00896339,0.00001533736,0.0000402367,0.0001469078,0.00005692518,0.001036349,0.9837161,0.00004566313,0.005289417,0.000007352639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907827,0.001931812,0.001212876,0.0001661197,0.000101774,0.00004629536,0.002356387,0.0001587239,0.003243286],"genre_scores_gemma":[0.9863899,0.00120641,0.001213465,0.0001298195,0.00001344043,0.00009943347,0.002418196,0.0000380687,0.008491295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00330077,"threshold_uncertainty_score":0.01104212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09930939092711356,"score_gpt":0.4134523697647558,"score_spread":0.3141429788376423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}