{"id":"W2334423299","doi":"10.1093/neuonc/nou240.32","title":"BM-32 * CERITINIB (LDK378) FOR TREATMENT OF PATIENTS WITH ALK-REARRANGED (ALK+) NON-SMALL CELL LUNG CANCER (NSCLC) AND BRAIN METASTASES (BM) IN THE ASCEND-1 TRIAL","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ceritinib; Medicine; Internal medicine; non-small cell lung cancer (NSCLC); Lung cancer; Cohort; Anaplastic lymphoma kinase; ALK inhibitor; Gastroenterology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001648156,0.0002176961,0.0005807335,0.0001033524,0.00008493386,0.00001192543,0.00007667328,0.00009188199,0.00003878483],"category_scores_gemma":[0.00007622659,0.0001300694,0.00009556206,0.0001298773,0.00009892914,0.00004320176,0.00001487907,0.00007790024,0.000001146949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020264,"about_ca_system_score_gemma":0.0003718093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005373616,"about_ca_topic_score_gemma":0.0008609518,"domain_scores_codex":[0.9986424,0.0002302888,0.0003247491,0.0003508464,0.0001576828,0.0002939782],"domain_scores_gemma":[0.9984115,0.0009399256,0.0001933521,0.0002577746,0.0001011183,0.00009636909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1573859,0.0250894,0.3016954,0.001242498,0.002273592,0.0002557962,0.03668634,0.000165838,0.03313,0.0004742904,0.02290713,0.4186938],"study_design_scores_gemma":[0.4329718,0.05090313,0.05004808,0.0001281687,0.003737147,0.00002296861,0.001028936,0.0002999309,0.008216529,0.00003434558,0.4522212,0.0003877462],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877862,0.0003883676,0.0001115914,0.003315766,0.0003186729,0.004174929,0.0002744851,0.00001700269,0.003612976],"genre_scores_gemma":[0.995723,0.0001343526,0.000591136,0.00157193,0.0002423975,0.001411776,0.0001705844,0.0000363748,0.0001184291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.429314,"threshold_uncertainty_score":0.5304077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02061837625935031,"score_gpt":0.3402370285325326,"score_spread":0.3196186522731823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}