{"id":"W2334423299","doi":"10.1093/neuonc/nou240.32","title":"BM-32 * CERITINIB (LDK378) FOR TREATMENT OF PATIENTS WITH ALK-REARRANGED (ALK+) NON-SMALL CELL LUNG CANCER (NSCLC) AND BRAIN METASTASES (BM) IN THE ASCEND-1 TRIAL","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ceritinib; Medicine; Internal medicine; non-small cell lung cancer (NSCLC); Lung cancer; Cohort; Anaplastic lymphoma kinase; ALK inhibitor; Gastroenterology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001437759,0.0008169841,0.001376178,0.0002305491,0.000257207,0.0005005567,0.0004236129,0.0005033142,0.002241433],"category_scores_gemma":[0.0006401385,0.000198667,0.0008475073,0.0002375863,0.0003674718,0.0004823141,0.000317639,0.001532067,0.0004432233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007409881,"about_ca_system_score_gemma":0.0008485601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007004845,"about_ca_topic_score_gemma":0.003014069,"domain_scores_codex":[0.9996748,0.0001754114,0.00001840765,0.00004544614,0.00003212145,0.00005384997],"domain_scores_gemma":[0.9996711,0.00004329758,0.000088481,0.00001537556,0.00002118879,0.0001606355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8133072,0.005644441,0.01892127,0.001345575,0.001808552,0.0003400322,0.0001610316,0.0026416,0.01638086,0.0002479738,0.01004354,0.1291579],"study_design_scores_gemma":[0.6936477,0.1956742,0.08791867,0.0001889427,0.00168908,0.001323434,0.0000848193,0.003679109,0.005257059,0.0005243905,0.00995987,0.00005278391],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890591,0.006590846,0.0002312216,0.0005958148,0.0001112204,0.0006144915,0.000942782,0.0000884612,0.001766154],"genre_scores_gemma":[0.9940347,0.001728812,0.0003670255,0.0003170317,0.0001063516,0.0003395969,0.001976015,0.000009930562,0.001120657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002241433,"threshold_uncertainty_score":0.007603645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02061837625935031,"score_gpt":0.3402370285325326,"score_spread":0.3196186522731823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}