{"id":"W2334525960","doi":"10.1016/j.jmoldx.2016.01.005","title":"Defining and Assessing Analytical Performance Criteria for Transmissible Spongiform Encephalopathy–Detecting Amyloid Seeding Assays","year":2016,"lang":"en","type":"article","venue":"Journal of Molecular Diagnostics","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nova Scotia Department of Agriculture; Canadian Food Inspection Agency","funders":"Alberta Livestock and Meat Agency","keywords":"Bovine spongiform encephalopathy; Seeding; Transmissible spongiform encephalopathy; Prion protein; Virology; Amyloid (mycology); Amyloid β; Biology; Medicine; Pathology; Scrapie; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007600611,0.000171439,0.0002321386,0.00009669106,0.0001386906,0.0001023076,0.0001681882,0.0001260978,0.00001074469],"category_scores_gemma":[0.001906853,0.0001307819,0.0001682547,0.00007839489,0.00005982711,0.00003483192,0.00006146301,0.0001067858,6.995379e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000267782,"about_ca_system_score_gemma":0.0001263492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.151276e-7,"about_ca_topic_score_gemma":3.067266e-7,"domain_scores_codex":[0.9988042,0.00005020438,0.0004238125,0.0002108034,0.0002043293,0.0003066186],"domain_scores_gemma":[0.998935,0.0002205358,0.0002693825,0.0001369056,0.0002381187,0.0002000283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001445842,0.00004134344,0.01594412,0.0001075605,0.00008733744,0.00004871988,0.00003877926,0.00006273035,0.8170301,0.0002031755,0.0001259053,0.1661656],"study_design_scores_gemma":[0.002777914,0.001549661,0.01416588,0.001331981,0.0003372739,0.0005430557,0.0001891309,0.002061494,0.9689144,0.0006789797,0.006849224,0.0006009773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8243621,0.009053705,0.1660832,0.0001785989,0.0001484323,0.0001009133,0.00001283028,0.000005101934,0.00005509376],"genre_scores_gemma":[0.9809397,0.004266161,0.01438065,0.0001107572,0.0002533436,0.000006202406,0.000003671058,0.00003039824,0.00000914752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1655647,"threshold_uncertainty_score":0.5333131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01244226790680285,"score_gpt":0.289183118630006,"score_spread":0.2767408507232031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}