{"id":"W2334612362","doi":"10.1124/dmd.114.060970","title":"Breast Cancer Resistance Protein Substrate and Inhibition Evaluation: Why, When, and How?","year":2014,"lang":"en","type":"letter","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Breast cancer; Human breast; Substrate (aquarium); Drug discovery; Drug resistance; Cancer; Computational biology; Biology; Chemistry; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000488987,0.0004336465,0.0006409212,0.0001572217,0.000220624,0.0001558635,0.0000418628,0.0004482607,0.0001281221],"category_scores_gemma":[0.000006101671,0.0003636542,0.00007918371,0.000117292,0.0002049295,0.0002901045,0.00002154493,0.0006069806,0.000002769757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000411404,"about_ca_system_score_gemma":0.00007551683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008654759,"about_ca_topic_score_gemma":0.000197474,"domain_scores_codex":[0.9978536,0.0001692388,0.0002778692,0.0007110803,0.0006562014,0.0003320245],"domain_scores_gemma":[0.9990924,0.00002065574,0.0002262756,0.0002714954,0.0002296852,0.0001595154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001452657,0.0001380555,0.0007252277,0.007436169,0.0003504952,0.0004425255,0.00162342,9.879566e-7,0.02681123,0.002667564,0.9383627,0.01998892],"study_design_scores_gemma":[0.01128091,0.00009000488,0.09295838,0.007023461,0.00719586,0.0006302702,0.0002809901,0.0002577703,0.01014426,0.01746624,0.8503991,0.002272795],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2730869,0.01827976,0.0005364963,0.7044701,0.0003313903,0.002000958,0.0004725682,0.00008991826,0.0007319048],"genre_scores_gemma":[0.7283093,0.005368426,0.001550555,0.2382506,0.007508309,0.001259693,0.004709902,0.0002244327,0.01281879],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4662195,"threshold_uncertainty_score":0.9998816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116764448990846,"score_gpt":0.2350341425892483,"score_spread":0.2233576976901637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}