{"id":"W2334612362","doi":"10.1124/dmd.114.060970","title":"Breast Cancer Resistance Protein Substrate and Inhibition Evaluation: Why, When, and How?","year":2014,"lang":"en","type":"letter","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Breast cancer; Human breast; Substrate (aquarium); Drug discovery; Drug resistance; Cancer; Computational biology; Biology; Chemistry; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00265867,0.0005129703,0.001267505,0.0004987156,0.001690785,0.002568339,0.001235234,0.02704699,0.004029098],"category_scores_gemma":[0.01635318,0.0004849774,0.001149829,0.0005276979,0.001906388,0.002643606,0.0007408726,0.01901622,0.003473248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004604646,"about_ca_system_score_gemma":0.003064155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003818548,"about_ca_topic_score_gemma":0.007357808,"domain_scores_codex":[0.9970624,0.001077327,0.0004273987,0.0002958015,0.0007688525,0.0003682165],"domain_scores_gemma":[0.9936405,0.00335774,0.0004358209,0.0001915127,0.001488312,0.0008861225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003271114,0.0001689734,0.005315277,0.0001341613,0.00004453925,0.009114805,0.0001369959,0.0003275968,0.0008976731,0.005272078,0.9090464,0.06921447],"study_design_scores_gemma":[0.0004939247,0.0005504756,0.005055279,0.0007472975,0.0001481894,0.02129534,0.0006231884,0.002770448,0.002042928,0.02348635,0.9426577,0.0001288266],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001189292,0.002062618,0.0002584619,0.9889426,0.004270136,0.00001347673,0.00004995921,0.00002813622,0.003185276],"genre_scores_gemma":[0.02328104,0.005105142,0.001847643,0.9229813,0.03881712,0.00005361863,0.00009103986,0.00004064389,0.00778245],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02704699,"threshold_uncertainty_score":0.03340924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116764448990846,"score_gpt":0.2350341425892483,"score_spread":0.2233576976901637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}