{"id":"W2334642566","doi":"10.1021/sb500045w","title":"A Multiplexed Transcription Activator-like Effector System for Detecting Specific DNA Sequences","year":2014,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Research Services, University of Calgary; Genome Alberta; Alberta Innovates; Alberta Innovates - Technology Futures","keywords":"DNA; Effector; Biology; DNA binding site; Transcription (linguistics); DNA-binding protein; DNA sequencing; Molecular biology; Genetics; Computational biology; Transcription factor; Promoter; Gene; Cell biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003477092,0.000206759,0.0002299553,0.00005199665,0.0001137116,0.00001778911,0.000192671,0.000267431,0.00000525016],"category_scores_gemma":[0.0001213677,0.0001856428,0.0001246483,0.00005758837,0.00008224489,0.00000271213,0.00002425503,0.00007867756,0.00001122822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002345585,"about_ca_system_score_gemma":0.00001587342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000013239,"about_ca_topic_score_gemma":0.00001291051,"domain_scores_codex":[0.9987819,0.0001147652,0.0002314187,0.000463583,0.00005151628,0.0003568598],"domain_scores_gemma":[0.9993635,0.0001123967,0.00007042081,0.0003323398,0.00004960809,0.00007170272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006995763,0.00001300117,0.0001456012,0.00008306825,0.00003558076,2.427649e-7,0.00005147727,0.00009652922,0.9854434,0.0001561441,0.00003953991,0.01386542],"study_design_scores_gemma":[0.0005815816,0.0004179513,0.0001895642,0.00003465805,0.00002267179,0.00003169764,0.0000989638,0.0004775086,0.9597347,0.00003831874,0.03813785,0.0002344757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8774219,0.0005443862,0.12038,0.00004802893,0.0009319707,0.0003962734,0.0000275083,0.00006380108,0.0001860733],"genre_scores_gemma":[0.9969245,0.00003434975,0.002283088,0.00003950993,0.00044396,0.0001337524,0.00006552657,0.00003393972,0.00004140252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1195025,"threshold_uncertainty_score":0.7570294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01163167100441974,"score_gpt":0.2754598127344996,"score_spread":0.2638281417300798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}