{"id":"W2334645423","doi":"10.1213/ane.0000000000001158","title":"Central Nervous System–Toxic Lidocaine Concentrations Unmask L-Type Ca2+ Current–Mediated Action Potentials in Rat Thalamocortical Neurons: An In Vitro Mechanism of Action Study","year":2016,"lang":"en","type":"article","venue":"Anesthesia & Analgesia","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"","keywords":"Lidocaine; Tetrodotoxin; Neuroscience; Veratridine; Neurotoxicity; Central nervous system; Electrophysiology; Medicine; Patch clamp; Pharmacology; Repolarization; Current clamp; Neuron; Sodium channel; Anesthesia; Biophysics; Chemistry; Toxicity; Internal medicine; Biology; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002510082,0.0003353764,0.0003963224,0.0001522078,0.0001339089,0.0003315889,0.0003549987,0.0002388694,0.001050785],"category_scores_gemma":[0.0001763771,0.000119052,0.0003984171,0.0001566685,0.0003282802,0.0003237206,0.0001732431,0.0005795446,0.0003235145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003144757,"about_ca_system_score_gemma":0.0002966311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199118,"about_ca_topic_score_gemma":0.002224157,"domain_scores_codex":[0.9998223,0.00002342163,0.0000234805,0.00003416194,0.00004278697,0.00005380432],"domain_scores_gemma":[0.999891,0.00003069262,0.000027384,0.00001819543,0.00001681879,0.00001580721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008913343,0.00002902414,0.0002200619,0.00005413924,0.000007147004,0.00006130376,0.0000218779,0.00002705807,0.9985977,0.00002358182,0.00001552003,0.0008533677],"study_design_scores_gemma":[0.00003471997,0.001035216,0.007389966,0.00001102121,0.00005392063,0.0003337606,0.00005939879,0.0007460435,0.9899031,0.00003074644,0.0003983982,0.000003751621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918887,0.003783371,0.002937063,0.00006304617,0.00002450874,0.00004854341,0.000161019,0.00003286344,0.001061029],"genre_scores_gemma":[0.9946073,0.002290493,0.002121719,0.00004347355,0.00002076452,0.00004601155,0.0002163498,0.0000139312,0.0006401482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199118,"threshold_uncertainty_score":0.003515303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07116002452749758,"score_gpt":0.3554936062528828,"score_spread":0.2843335817253852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}