{"id":"W2334651034","doi":"10.1186/s12967-016-0836-6","title":"A phase I study of high-dose rosuvastatin with standard dose erlotinib in patients with advanced solid malignancies","year":2016,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; Ottawa Hospital; Ottawa Regional Cancer Foundation; University of Ottawa; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Prostate Cancer Fight Foundation; Institute of Cancer Research; Ontario Institute for Cancer Research; Roche Canada","keywords":"Rosuvastatin; Medicine; Erlotinib; Toxicity; Dosing; Pharmacology; Pharmacokinetics; Rosuvastatin Calcium; Internal medicine; Maximum tolerated dose; Oncology; Epidermal growth factor receptor; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001943445,0.001544031,0.002256579,0.0005654848,0.000627001,0.001213806,0.001138194,0.001181285,0.00234417],"category_scores_gemma":[0.0009117051,0.0007973709,0.001788074,0.0007223423,0.001267664,0.001106196,0.0005015831,0.00401723,0.0007903802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001361908,"about_ca_system_score_gemma":0.002565231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008195321,"about_ca_topic_score_gemma":0.001966861,"domain_scores_codex":[0.9992908,0.0002974166,0.00004112101,0.0001414869,0.00008440872,0.0001447475],"domain_scores_gemma":[0.9989018,0.0001039452,0.0002432927,0.0001404769,0.0000775282,0.0005328774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5953017,0.1771378,0.01508262,0.001061255,0.00203072,0.000465671,0.00070761,0.004604363,0.1023836,0.0003398722,0.003318966,0.09756575],"study_design_scores_gemma":[0.3504947,0.6266556,0.01373661,0.0000223504,0.0003878209,0.0003717291,0.00007455029,0.001087843,0.004950735,0.000135504,0.002047734,0.00003486859],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945425,0.0009581574,0.0005235342,0.0002953005,0.0000644287,0.002381643,0.0004426786,0.00006103869,0.0007306429],"genre_scores_gemma":[0.9919897,0.0008217982,0.002124058,0.0004287857,0.0001060076,0.002581972,0.001002699,0.00002231411,0.0009226799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00234417,"threshold_uncertainty_score":0.01027799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008118803149594204,"score_gpt":0.2767590504885937,"score_spread":0.2686402473389995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}