{"id":"W2334664644","doi":"10.1016/j.jmb.2016.04.004","title":"Structural and Dynamics Studies of Pax5 Reveal Asymmetry in Stability and DNA Binding by the Paired Domain","year":2016,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; Genome British Columbia","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"DNA; Linker; CTD; DNA-binding domain; HMG-box; Binding site; Chemistry; Biophysics; DNA-binding protein; Transcription factor; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116872,0.000152631,0.0001370529,0.0001412649,0.0003169184,0.0002482808,0.000308956,0.0002492463,0.002846307],"category_scores_gemma":[0.0001853528,0.0001507294,0.0001779634,0.0001349959,0.0002861188,0.0003682193,0.0002604883,0.0005088935,0.0002255567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004610349,"about_ca_system_score_gemma":0.0001727174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001549828,"about_ca_topic_score_gemma":0.001996594,"domain_scores_codex":[0.9999448,0.00000595002,0.000002751076,0.00001228672,0.00002015709,0.00001411304],"domain_scores_gemma":[0.9999216,0.00002465471,0.00001642699,0.000005848043,0.000007953292,0.00002348095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004098382,0.00005030398,0.003123856,0.00004348981,0.00002185854,0.0001117171,0.00005474691,0.001848112,0.987163,0.002741124,0.0001885209,0.00424336],"study_design_scores_gemma":[0.00006520382,0.0001754501,0.02269221,0.0000112442,0.00002812025,0.0004202152,0.000206758,0.05821574,0.9147809,0.001216862,0.002154052,0.00003331976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977171,0.0001788819,0.001298784,0.00006564301,0.000006436196,0.000002016818,0.00005556495,0.00001492125,0.0006607478],"genre_scores_gemma":[0.9993383,0.00003524468,0.0003207188,0.00001270889,0.000001190222,0.000001132551,0.00005557001,0.000003416603,0.0002316252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002846307,"threshold_uncertainty_score":0.009521842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009237202970664724,"score_gpt":0.2554102730690279,"score_spread":0.2461730700983631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}