{"id":"W2334697425","doi":"10.1093/neuonc/nou275.5","title":"SC-05 * DOPAMINE RECEPTOR ANTAGONISTS ARE SELECTIVE INHIBITORS OF GLIOBLASTOMA STEM CELLS THROUGH IMPAIRMENT OF AUTOPHAGY","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Neural stem cell; Clonogenic assay; Cancer research; Cancer stem cell; Stem cell; Downregulation and upregulation; Autophagy; Biology; Temozolomide; Cell biology; Cell culture; Glioma; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005220968,0.0002909021,0.0002537204,0.0003004507,0.0001170688,0.0001701856,0.0001321081,0.000150918,0.001559395],"category_scores_gemma":[0.00004776835,0.0000784002,0.0001903162,0.0002175923,0.00009545842,0.00007649764,0.00008721701,0.0003505933,0.0004040905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440005,"about_ca_system_score_gemma":0.0003858827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120277,"about_ca_topic_score_gemma":0.004974878,"domain_scores_codex":[0.9999598,0.000005623403,0.000004321496,0.000005570304,0.00001039856,0.00001435553],"domain_scores_gemma":[0.999977,0.00000396232,0.000004059333,0.000002160522,0.00000386702,0.000008998898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007476567,0.0004077097,0.0006622375,0.0001959726,0.00003592625,0.0001682461,0.00002088927,0.0003019009,0.9731501,0.0003851735,0.001024726,0.0228994],"study_design_scores_gemma":[0.0002928461,0.005452742,0.007349659,0.00002999327,0.00007001819,0.0005577914,0.00003736241,0.001112567,0.9717283,0.0001386638,0.01321874,0.00001129023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856391,0.005593424,0.0009330494,0.0001568475,0.00003857661,0.0001065763,0.001051761,0.0001501061,0.00633068],"genre_scores_gemma":[0.9855577,0.004620865,0.001953451,0.0001750475,0.00001157961,0.0001060336,0.002252941,0.00001992586,0.005302367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559395,"threshold_uncertainty_score":0.005216718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00806125200810196,"score_gpt":0.2490774102121051,"score_spread":0.2410161582040031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}