{"id":"W2334755221","doi":"10.1042/bj20110985","title":"LRPPRC mutation suppresses cytochrome oxidase activity by altering mitochondrial RNA transcript stability in a mouse model","year":2011,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Pentatricopeptide repeat; Molecular biology; Mitochondrial DNA; Biology; Messenger RNA; Gene; Cytochrome c oxidase; Mitochondrion; Mutant; Genetics; RNA editing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001870581,0.0002292587,0.0002369652,0.00006840891,0.0000808769,0.00003624857,0.0002380614,0.0003307982,0.0001902583],"category_scores_gemma":[0.0001823739,0.0002201779,0.0001640946,0.00008059647,0.0001167162,0.00002286859,0.00005779364,0.0003805037,0.000006671658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005068478,"about_ca_system_score_gemma":0.0001105781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002737803,"about_ca_topic_score_gemma":0.00001775361,"domain_scores_codex":[0.998457,0.0001607858,0.0003798335,0.0004397577,0.0001853178,0.0003773091],"domain_scores_gemma":[0.9992514,0.00001471941,0.0001271034,0.0002766495,0.00009228668,0.0002378578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001169009,0.0003076243,0.0001223651,0.00001655038,0.00002243918,0.00001487899,0.0002061492,0.00002622172,0.9954759,0.00000521386,0.002361311,0.000272364],"study_design_scores_gemma":[0.00151265,0.0002272425,0.00009740258,0.00001025922,0.00001518065,0.0001222267,0.00004351269,0.0003430415,0.9969134,0.0001298618,0.0003406172,0.0002446442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595091,0.0001597986,0.03930424,0.00006171945,0.0003762495,0.0001924335,0.00009139132,0.00001672473,0.0002883178],"genre_scores_gemma":[0.9948589,0.00007886807,0.004260656,0.0001340474,0.0003766856,0.00002539019,0.00006194899,0.00002674817,0.0001767913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03534974,"threshold_uncertainty_score":0.8978593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03123226935322631,"score_gpt":0.2498905699018201,"score_spread":0.2186583005485938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}