{"id":"W2334755221","doi":"10.1042/bj20110985","title":"LRPPRC mutation suppresses cytochrome oxidase activity by altering mitochondrial RNA transcript stability in a mouse model","year":2011,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Pentatricopeptide repeat; Molecular biology; Mitochondrial DNA; Biology; Messenger RNA; Gene; Cytochrome c oxidase; Mitochondrion; Mutant; Genetics; RNA editing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004056644,0.0008590794,0.0004848327,0.000867924,0.0002787744,0.0004287764,0.000541247,0.0009039905,0.002448105],"category_scores_gemma":[0.0002656015,0.0003833492,0.0004944871,0.0002645229,0.0005772267,0.0002925313,0.0002698959,0.001187368,0.001047205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003520536,"about_ca_system_score_gemma":0.0002205628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004767926,"about_ca_topic_score_gemma":0.0004869943,"domain_scores_codex":[0.9995763,0.00008376075,0.00006480614,0.0001110967,0.00008653456,0.00007750098],"domain_scores_gemma":[0.9994684,0.00009046319,0.0001891661,0.00007293907,0.00003313258,0.0001458914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001987972,0.0001180897,0.0001141662,0.00002383937,0.000007750559,0.0002088374,0.00001644884,0.00004609986,0.9984282,0.0001403083,0.00005539617,0.0006420699],"study_design_scores_gemma":[0.0001497769,0.001338122,0.002694467,0.00001869468,0.00005352218,0.001794938,0.00003857573,0.001369466,0.9895215,0.0001133696,0.002894984,0.00001258102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928812,0.0008542766,0.003569361,0.0002098778,0.00005972938,0.00008167496,0.0005338218,0.0004196814,0.00139026],"genre_scores_gemma":[0.9878243,0.0009427677,0.003464431,0.0001090424,0.00004471988,0.0001603709,0.0009586599,0.0001582587,0.00633742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002448105,"threshold_uncertainty_score":0.008189738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03123226935322631,"score_gpt":0.2498905699018201,"score_spread":0.2186583005485938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}