{"id":"W2334773060","doi":"10.1021/mp500658w","title":"Effect of Polyethylene Glycol Conjugation on Conformational and Colloidal Stability of a Monoclonal Antibody Antigen-Binding Fragment (Fab′)","year":2014,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Polyethylene glycol; PEGylation; Chemistry; PEG ratio; Circular dichroism; Immunoglobulin Fab Fragments; Steric effects; Colloid; Biophysics; Chromatography; Crystallography; Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002475452,0.0002671635,0.0001415662,0.00008341685,0.00007004008,0.0001518599,0.0001319772,0.0001490846,0.0005270696],"category_scores_gemma":[0.0004379707,0.0001057945,0.0001524766,0.00009773012,0.0001357496,0.0002154858,0.00009962366,0.0002400144,0.00008424342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001492557,"about_ca_system_score_gemma":0.0001020107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004792211,"about_ca_topic_score_gemma":0.000455319,"domain_scores_codex":[0.9998971,0.0000247016,0.00001028918,0.00002204322,0.00002513595,0.00002071045],"domain_scores_gemma":[0.9998081,0.00007879454,0.00005492253,0.00001416653,0.00002249966,0.00002151737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001216825,0.00002282155,0.0001744498,0.00002055343,0.000006271498,0.00002242732,0.0000138322,0.0001191199,0.9983647,0.00001767422,0.000005790521,0.001110608],"study_design_scores_gemma":[0.00000678528,0.0003891933,0.001426984,0.000001866255,0.0000148765,0.0000434607,0.000004686612,0.0003650891,0.9975169,0.000007302133,0.0002205176,0.000002422065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990006,0.0002648417,0.0005045671,0.00001338783,0.000003941545,0.000005199551,0.0000211785,0.000008698246,0.0001776162],"genre_scores_gemma":[0.9987418,0.0002198687,0.0007333321,0.00001911979,0.000002943187,0.000004702464,0.00004418086,0.000006371536,0.0002278057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005270696,"threshold_uncertainty_score":0.001763284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01988069217433994,"score_gpt":0.3666123484529727,"score_spread":0.3467316562786327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}