{"id":"W2334773060","doi":"10.1021/mp500658w","title":"Effect of Polyethylene Glycol Conjugation on Conformational and Colloidal Stability of a Monoclonal Antibody Antigen-Binding Fragment (Fab′)","year":2014,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Polyethylene glycol; PEGylation; Chemistry; PEG ratio; Circular dichroism; Immunoglobulin Fab Fragments; Steric effects; Colloid; Biophysics; Chromatography; Crystallography; Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009996743,0.0002028397,0.00045563,0.0001617868,0.0000761305,0.00001173284,0.00009489196,0.00009555077,0.0001170577],"category_scores_gemma":[0.0001718886,0.0001686021,0.0001310157,0.0001789462,0.0002619642,0.0000518825,0.00008287719,0.0002557683,0.000008704275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004673589,"about_ca_system_score_gemma":0.00009210212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000360503,"about_ca_topic_score_gemma":5.881016e-7,"domain_scores_codex":[0.9980192,0.0002572876,0.0004613451,0.0002275567,0.0007635972,0.0002710065],"domain_scores_gemma":[0.9988347,0.0003913004,0.0001811993,0.000194326,0.0002015098,0.0001969102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002278031,0.0001927227,0.0553644,0.0009146818,0.0001656301,0.00001133517,0.0001507017,0.00004319004,0.933957,0.001333748,0.00002087389,0.005567731],"study_design_scores_gemma":[0.003022508,0.002024007,0.009750067,0.0001351028,0.00009377122,0.00002744482,0.000021881,0.01026655,0.9726015,0.00004132264,0.001884675,0.0001311499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958379,0.0002630232,0.0007053458,0.0003604705,0.0000802237,0.0007621903,0.00009470609,0.00001521822,0.001880927],"genre_scores_gemma":[0.9989616,0.0001517887,0.0003980658,0.0002292041,0.00004355475,0.00001347379,0.0001450246,0.00001648739,0.00004081734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04561434,"threshold_uncertainty_score":0.6875395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01988069217433994,"score_gpt":0.3666123484529727,"score_spread":0.3467316562786327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}