{"id":"W2334874614","doi":"10.1093/neuonc/nov061.33","title":"GE-09 * COMBINED HEREDITARY AND SOMATIC MUTATIONS OF REPLICATION ERROR REPAIR GENES RESULT IN RAPID ONSET OF ULTRA-HYPERMUTATED MALIGNANT BRAIN TUMORS IN CHILDREN","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Somatic cell; Replication (statistics); Genetics; Gene; Biology; Mutation; Germline mutation; Cancer research; Medicine; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001127594,0.0004917022,0.0002661897,0.000607391,0.0002816281,0.0002763763,0.0001832673,0.0003140805,0.004276322],"category_scores_gemma":[0.0002590851,0.000206151,0.0002610686,0.0004341698,0.0002651203,0.0001148168,0.000348528,0.0003746454,0.000954915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003225912,"about_ca_system_score_gemma":0.0002728613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001816876,"about_ca_topic_score_gemma":0.002930856,"domain_scores_codex":[0.9998042,0.00001927076,0.00001148425,0.00006489625,0.00005000853,0.00005015061],"domain_scores_gemma":[0.9998534,0.00003933888,0.00004182877,0.00001293501,0.0000141905,0.00003831358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001388203,0.000191961,0.5807637,0.0002469987,0.0003716761,0.03245277,0.0004584478,0.0006120637,0.336897,0.001087217,0.004322352,0.04120758],"study_design_scores_gemma":[0.00003445643,0.00051977,0.8287992,0.00004550054,0.0001096751,0.09888027,0.0003474618,0.0004725337,0.0487974,0.0001909272,0.02178442,0.00001831208],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923745,0.0004409982,0.000656048,0.00007049064,0.0000111713,0.00001658894,0.003300445,0.00008591053,0.003044018],"genre_scores_gemma":[0.9913149,0.000474469,0.002473336,0.00006015868,0.000007928116,0.00001868407,0.00348118,0.00005767198,0.00211168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004276322,"threshold_uncertainty_score":0.01430577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03043287086740363,"score_gpt":0.3078961192213144,"score_spread":0.2774632483539107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}