{"id":"W2334892627","doi":"10.1158/1538-7445.am2013-597","title":"Abstract 597: The combination of valproic acid and fludarabine treatment induces a synergistic apoptotic response in chronic lymphocytic leukemia (CLL) patients involving the lysosomal protease cathepsin B.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Manitoba","funders":"","keywords":"Fludarabine; XIAP; Chronic lymphocytic leukemia; Cathepsin B; Cancer research; Cathepsin; Apoptosis; Vorinostat; Caspase; Chemistry; Pharmacology; Histone deacetylase; Leukemia; Programmed cell death; Medicine; Immunology; Biochemistry; Internal medicine; Histone; Chemotherapy; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009695283,0.0003609206,0.0004475605,0.0002056216,0.0001742261,0.0002373889,0.000160326,0.0003443108,0.003069154],"category_scores_gemma":[0.00009290279,0.0001247088,0.0003555039,0.0001594638,0.0001594632,0.0001091366,0.0001947777,0.0005291493,0.0006281311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002002083,"about_ca_system_score_gemma":0.0002343712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000326512,"about_ca_topic_score_gemma":0.000742285,"domain_scores_codex":[0.9998887,0.00002506637,0.00001063267,0.00001768611,0.00002146581,0.00003649765],"domain_scores_gemma":[0.9999498,0.000008578088,0.000007258056,0.000004798092,0.000005345883,0.00002418815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005209895,0.0006085738,0.001592221,0.0002343541,0.00006289947,0.0008310423,0.0000410539,0.0001179771,0.9741218,0.0000773932,0.001231565,0.01587116],"study_design_scores_gemma":[0.002444576,0.03211411,0.04792237,0.00006719003,0.000339006,0.01054504,0.0001357116,0.001162507,0.8787638,0.0001350667,0.02634337,0.00002724228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914966,0.00458697,0.0004040318,0.0002310497,0.0001729821,0.0001016183,0.0004895321,0.00007351344,0.002443693],"genre_scores_gemma":[0.9959276,0.0009829882,0.0006043155,0.0001317763,0.00004536387,0.00006495634,0.0009294474,0.000007796482,0.001305778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003069154,"threshold_uncertainty_score":0.01026738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05297574096075227,"score_gpt":0.3561570954377193,"score_spread":0.3031813544769671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}