{"id":"W2335017796","doi":"10.1158/1538-7445.am2011-lb-380","title":"Abstract LB-380: Direct targeting of the Hedgehog pathway in primary chondrosarcoma xenografts with the Smoothened inhibitor IPI-926","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Hospital for Sick Children","funders":"","keywords":"Smoothened; GLI1; PTCH1; Hedgehog; Hedgehog signaling pathway; Cancer research; Chondrosarcoma; Patched; Medicine; Cyclopamine; Biology; Pathology; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334139,0.0004675023,0.000536168,0.0002923771,0.0001591304,0.0002556891,0.0003376443,0.000258144,0.001479293],"category_scores_gemma":[0.00006698145,0.0001677725,0.0003036669,0.0002541181,0.0002169375,0.0001836567,0.0001346504,0.0008152592,0.0005028445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003693554,"about_ca_system_score_gemma":0.0004143764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0022829,"about_ca_topic_score_gemma":0.003207111,"domain_scores_codex":[0.9998606,0.00001528768,0.00001313712,0.00002159955,0.00004896656,0.00004037837],"domain_scores_gemma":[0.9999119,0.00001175485,0.00001805656,0.000009969584,0.00001159313,0.00003677011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005240368,0.0003210081,0.0001505459,0.00007302174,0.00001183424,0.00004550184,0.00001756433,0.0001791448,0.9962603,0.00007092807,0.000166553,0.002179587],"study_design_scores_gemma":[0.0001491369,0.00433769,0.002585715,0.000006817817,0.00003382345,0.0001881029,0.00002973059,0.0009330875,0.9901556,0.00001765085,0.001557729,0.000004998698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930252,0.001377341,0.001485327,0.0001192022,0.00004957146,0.0001130569,0.001065483,0.0001899036,0.002574982],"genre_scores_gemma":[0.9912673,0.001089964,0.002203687,0.00004883263,0.00001402895,0.0001165159,0.001756056,0.00003364071,0.003469972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0022829,"threshold_uncertainty_score":0.004948735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05204589060826312,"score_gpt":0.3050321828572872,"score_spread":0.2529862922490241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}