{"id":"W2335017796","doi":"10.1158/1538-7445.am2011-lb-380","title":"Abstract LB-380: Direct targeting of the Hedgehog pathway in primary chondrosarcoma xenografts with the Smoothened inhibitor IPI-926","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Hospital for Sick Children","funders":"","keywords":"Smoothened; GLI1; PTCH1; Hedgehog; Hedgehog signaling pathway; Cancer research; Chondrosarcoma; Patched; Medicine; Cyclopamine; Biology; Pathology; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00131364,0.0001859438,0.0002248126,0.00007784737,0.0002524079,0.00002113648,0.0006602166,0.0001204486,0.00003540466],"category_scores_gemma":[0.0001693475,0.0001028848,0.00009408432,0.0004568831,0.0006750894,0.000006728161,0.0004033516,0.0004302134,0.000004868882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007815268,"about_ca_system_score_gemma":0.0004600255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004534278,"about_ca_topic_score_gemma":0.0005452764,"domain_scores_codex":[0.9979594,0.0002950607,0.000269786,0.0004241559,0.0004861304,0.0005654766],"domain_scores_gemma":[0.9988596,0.00008809253,0.0001085715,0.0006000769,0.0002770773,0.00006661108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003049777,0.00009761011,0.01783964,0.00009774779,0.00006615182,0.000008782747,0.001532375,0.00002185926,0.9764961,0.00001154415,0.002253281,0.001269935],"study_design_scores_gemma":[0.0005331457,0.0001894054,0.07563493,0.0001546367,0.000005094969,0.000001653567,0.0004720271,0.000001476859,0.9118848,0.00002206819,0.01094143,0.0001593502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891514,0.004001486,0.000004535354,0.0003002924,0.0001427918,0.0005569544,0.0000414858,0.000009105441,0.005791957],"genre_scores_gemma":[0.9983696,0.0002160062,0.00007125411,0.0001067446,0.0003027658,0.0002503303,0.00001008082,0.00004250842,0.0006307382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06461132,"threshold_uncertainty_score":0.4195521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05204589060826312,"score_gpt":0.3050321828572872,"score_spread":0.2529862922490241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}